The science-backed safety profile of creatine supplementation, addressing myths, clinical evidence, and long-term outcomes in +650 human studies

madman

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Kreider, R. B., Gonzalez, D. E., Hines, K., Gil, A., & Bonilla, D. A. (2025). Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports. Journal of the International Society of Sports Nutrition, 22(sup1). https://doi.org/10.1080/15502783.2025...





The Creatine Conference 2025 welcomes Prof. Rick Kreider, PhD (ESNL, Texas A&M University), a leading global expert on creatine research. In this keynote, Dr. Kreider examines the science-backed safety profile of creatine supplementation, addressing myths, clinical evidence, and long-term outcomes in +650 human studies.

Dr. Kreider serves as Professor and Director of the Exercise & Sport Nutrition Lab and Director of the Human Clinical Core at Texas A&M University. He has published 12 books (including translations), over 300 peer-reviewed articles and book chapters, 500 research abstracts, and 150 health and fitness-related articles. According to Google Scholar, his work has been cited over 27,800 times in the literature (h-index 82, i10-index 213).

The Creatine Conference 2025 brings together the world’s leading creatine researchers to advance awareness of creatine monohydrate supplementation’s role in health and clinical conditions. Event hosted by Alzchem Group AG, the Exercise and Sport Nutrition Laboratory at Texas A&M, and the DBSS Research Division.
 
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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