This paper is a classic example of single-variable-fallacy. The Vitamin D gurus (e.g. masterjohn. hollick) are consistent in saying that if one is supplementing with oral vitamin D then it is essential to supplement with vitamin K2 as well since K2 is involved in the regulation of calcium storage. I think magnesium and Vitamin A are also important for proper use of Vitamin D. There is now a good body of evidence that Vitamin D blood levels of 50 are a good level to shoot for and that is not achievable for most people (except with good sun exposure) without supplementation.There is no drug or supplement that has only positive effects. One should supplement vit D only when their levels are low.
Role of vitamin D in vascular calcification: bad guy or good guy?
The role of vitamin D and its derivatives in vascular calcification is complex. It has long been known that in humans, hypervitaminosis D may be associatedacademic.oup.com