The Death of the ‘Testosterone Causes Prostate Cancer’ Myth: What Every Man on HRT Needs to Know

[madman]

Great presentation by the leading expert in the field!




Abraham Morgentaler

For 80 years the question has been:

Wrong question

The right question:

Conclusions

 

[madman]

Eight decades later!




Androgen Hypothesis - Traditional Teaching For >80 Years

 

[madman]

Goalposts shifted over time

Impact

 

[madman]

FDA label for all testosterone products

 

[madman]

Where did this belief come from?

Huggins 1966 Nobel lecture

 

[madman]

Predictions of the Androgen Hypothesis

Predictions of "T Drives Prostate Cancer"

Prostate biopsy studies - PCPT and REDUCE

Abraham Morgentaler

* endogenous testosterone levels are not associated with prostate cancer risk

 

[madman]

Predictions of "T Drives Prostate Cancer"

TRAVERSE trial

Meta-analysis and systemic review

T therapy associated with reduced rate of PCa

 

[madman]

Predictions of "T Drives Prostate Cancer"

Low Testosterone Levels Associated With High-Grade Prostate Cancer

T Therapy Associated with Lower Risk of Aggressive Cancer

 

[madman]

Predictions of "T Drives Prostate Cancer"

T therapy after radical prostatectomy

T therapy does not increase progression rates on active surveillance

T Therapy in men with biochemical recurrence and metastatic PCa

 

[madman]

Right??

Supporting studies?

 

[madman]

But what about...?

There is always an article

 

[madman]

For 80 years the question has been:

Wrong question

The right question:

 

[madman]

A Mystery

We have lived through 80+ years of mass hysteria

 

[madman]

Conclusions

 

[madman]

Eye opener here!



Abraham Morgentaler

* This is a misleading way of presenting it and this is my own slide so I'll take responsibility. The problem is that there is no occurrence in actual life where a mature male has a testosterone of. zero without a previous intervention and the better way to present this is to show decraesing serum testosterone




Saturation Model

 

[madman]

Thread 'Testosterone Replacement After Prostate Cancer: Safety, Benefits & Latest Research Uncovered'

Aug 9, 2025

* Gaps in long-term data and areas for further research are identified, underscoring the need for careful application in clinical practice. This paper emphasises a multidisciplinary approach in patient selection, rigorous monitoring protocols, and fully informed decision-making. By presenting a comprehensive review of the evidence, we aim to clarify the role of TRT in improving quality of life for men in remission from prostate cancer, while ensuring that oncological safety remains the highest priority.




Table 1 Comparison of TRT Guidelines from BSSM, AUA, and EAU...

• madman
• pca/active surveillance; testosterone therapy
• Replies: 5
• Forum: Prostate Related Issues