The 1st FDA approved oral Testosterone: Meet Kyzatrex®

madman · 2026-01-20T21:04:22-0600

Founder, CEO, and visionary behind Marius Pharmaceuticals, the company that brought Kyzatrex to market—the first FDA-approved oral testosterone replacement therapy. With a background in private equity and investing, he moved into biotech to solve a long-standing problem in hormone health: making testosterone therapy more accessible, more practical, and aligned with modern lifestyles—while supporting education, stigma reduction, and better men’s health outcomes.

In this two-part roundtable, the Biohacking Brothers sit down with Shalin Shah to break down why testosterone is a foundational longevity hormone, how Kyzatrex became the first FDA-approved oral testosterone, and what makes oral pulsatile dosing different from traditional injections. They cover cardiovascular and cognitive implications, stigma and access, fertility concerns, SHBG and free testosterone, estrogen myths, safety markers like hematocrit, and why patient education and proper lab interpretation matter—especially in a world where testosterone levels are declining across younger men.

Chapters

00:00 FDA-Approved Oral Testosterone
01:15 Who Is Shalin Shah
02:50 From Private Equity to HRT
03:45 The 2014 Testosterone Scare
05:10 Testosterone & Public Health
07:15 Heart and Brain Receptors
09:05 Brain Fog and Cognition
10:55 Testosterone Decline in Young Men
12:10 Symptoms vs Lab Ranges
20:45 Oral Testosterone Myths
22:30 How Kyzatrex Bypasses the Liver
23:40 Pulsatile Dosing Explained

madman · 2026-01-20T21:06:24-0600

Thread 'Pill vs. Needle: The science behind the new oral therapy replacing injections'

Saturday at 10:40 PM

Men are living, on average, 7 years less than women. According to Shalin Shah, CEO of Marius Pharmaceuticals, the medical community has ignored a cause for decades due to stigma, "gym bro" stereotypes, and outdated science.

In this episode, Daniel Robbins sits down with Shalin Shah to reveal why he believes testosterone is "less abused than caffeine" and yet still overly restricted. Shalin breaks down the "10 Cups of Coffee" rule (why weekly injections are bad for your body) and how he achieved FDA approval for an oral testosterone pill that mimics the body's...