TESTOSTERONE: A SAFETY UPDATE 2025

[madman]

Thread 'Testosterone Therapy and Erythrocytosis - the most common dose-limiting effect of testosterone therapy'

Apr 21, 2024

Testosterone Therapy and Erythrocytosis • The Blood Project

Introduction Androgens play a crucial role in the development and maintenance of: Male reproductive and sexual functions Body composition Erythropoiesis

www.thebloodproject.com

Introduction

• Androgens play a crucial role in the development and maintenance of:
  
  • Male reproductive and sexual functions
  • Body composition
  • Erythropoiesis
  • Muscle and bone health
  • Cognitive function
• Testosterone falls progressively with age and a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young...

• madman
• hypogonadism; testosterone; hematocrit; cvd
• Replies: 21
• Forum: Testosterone Side Effect Management

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[madman]

Thread 'Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol'

Oct 12, 2025

Hot off the press!

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas!

Great presentation!




1:29:40-1:43:30

Conclusions

• madman
• t-therapy; side effects; erythrocytosis; estradiol
• Replies: 34
• Forum: Testosterone Side Effect Management

 

[madman]

Thread 'Dr. Shalender Bhasin: Optimizing the Diagnosis and Treatment of Hypogonadism 2025'

Oct 7, 2025

Nelson's house u heard it here first!

Dr. Shalender Bhasin!

* over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its informed public health policy particularly around testosterone therapy, anabolic interventions and then the development of function promoting therapies




Pay attention to 25:40-34:36 of the presentation where he explains the importance of measuring free testosterone using a standardized Equilibrium Dialysis method!

Explains the...

• madman
• hypogonadism; diagnosis/treatment; trt
• Replies: 33
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'EAU Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Hypogonadism, ED, Premature Ejaculation'

Nov 29, 2025

* Elevated haematocrit is common with TTh, typically occurring within 3–12 mo. Levels up to 54% appear safe, but higher values may increase CV risk [15].


* Treatment adjustments are required for haematocrit >54% (requiring withdrawal and phlebotomy in high-risk cases)

Fig. 1 – Diagnostic evaluation of late-onset hypogonadism. cFT = calculated free testosterone; LH = luteinising hormone; MRI = magnetic resonance imaging; PRL = prolactin; SHBG = sex hormone–binding globulin; T =...

• madman
• hypogonadism; eau guidelines; t-therapy; health
• Replies: 9
• Forum: Testosterone and Men's Health Articles

 

[madman]

Post in thread 'Functional Hypogonadism Uncovered: The Truth About Modern Testosterone Therapy and Men’s Health'

Feb 11, 2026

GANGSTARR

* Aside from TRAVERSE, meta-analyses have now concluded that TTh, in doses restoring physiological levels, is not associated with elevated cardiovascular risk.


* One safety consideration that does remain is erythrocytosis. As noted, testosterone often raises hematocrit. In T4DM, for example, about 20% of men on testosterone developed hematocrit >54%, versus 1% on placebo [16]. Similar results were observed in the HEAT-registry [19]. While an increased red cell mass can be beneficial up to a point (alleviating anemia), excessive erythrocytosis...

• madman