TestoGel absorption rates - my observations: Are we overdosing with scrotum application?

Mr Muc.

New Member
Hello everyone,

I would like to discuss the following findings with you.

A fit teenager produces approx. 7-10mg of testosterone per day. This would also be the dose that should be calculated as a "natural" substitute. But now the question keeps coming up of how much gel/cream is needed?

Classic transdermal application:
100mg testosterone
-> Deliver approx. 850 ng/dl (30 nmol/l)


1706265867728.png



Scrotum application:
50mg testosterone
-> deliver approx. 700ng/dl

1706266102590.png




If you now consider the approx. 7-10mg that are required (for a teenager) to reach 800-1000 ng/dl, the result for:
  1. Classic transdermal (shoulder, upper arms ect) an absorption rate of ~10%
  2. For scrotum it is "almost" twice as much at just under ~17% - BUT not three times or more what has been stated in many forum posts...??
    -> Here, however, the testosteron values fall much faster than with the classic application and possibly more is converted into DHT ect.
What I am wondering now is why dosages of 200mg cream are often applied to scrotum and recommended? The result would then have to go far beyond the natural range of 800-1000 ng/dl - and the free test values are often more important than total testosterone, aren't they?

This also fits in with my observations. With 125mg testosterone (mix Shoulder and Scrotum) I felt overdosed and unwell (tired, unfocused, dull). My Labs showed values double and tripple over max range!

I am currently experimenting with approx. 30mg testosterone on Scrotum only 1-2x a day and feel much better. will also test with mixed areas eg. morning scrotum and evening shoulders (for a more steady state)

Looking forward to your Insight and thoughts
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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