Testicular Cancer Fundamentals

madman

Super Moderator

In this video, the speaker discusses the fundamentals of testicular cancer and emphasizes the importance of optimizing the care for young men with this disease. While testicular cancer is highly curable, it can lead to long-term toxicity due to treatments such as chemotherapy. The speaker suggests novel approaches to minimize toxicity and improve long-term cancer control. They also mention the need to address delays in diagnosis and provide comprehensive care for patients, including fertility preservation and emotional support.


Key Takeaways:


  • Testicular cancer is highly curable but can cause long-term toxicity
  • It is the most common cancer in men aged 18-45
  • Minimizing toxicity and maintaining excellent cancer control is crucial
  • Screening for testicular cancer is not recommended, but risk factors should be considered
  • Microcalcifications in testicles (microlithiasis) do not necessarily indicate higher cancer risk
  • Testicular cancer can present with various symptoms, including abdominal and back pain
  • Comprehensive physical exams and scrotal exams are important for diagnosis (
  • Tumor marker tests and ultrasound should be conducted before surgery
  • Staging imaging should be done before orchiectomy to avoid misleading results
  • Discussing testicular prosthesis and fertility concerns is essential
  • Surveillance is the preferred option for stage 1 seminoma, while other treatments are considered for stage 2 and non-seminoma
  • Efforts are being made to reduce the long-term toxicities of chemotherapy and radiation
  • Primary RPD may be curative for non-seminoma, regardless of nodal burden
  • Long-term side effects of treatment should be minimized and managed effectively
 
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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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