madman
Super Moderator
Cure rates for stage 1 testicular cancer are reaching 100%. However, long-term treatment-related side effects pose their own health risks. Regular follow up and monitoring are important for early detection and timely treatment of conditions such as testosterone deficiency and metabolic syndrome.
Testosterone deficiency following testicular cancer
Possible mechanisms for TD following TC
A low testosterone level may be present when TC is diagnosed, or it may follow treatment for the disease.
Causes of TD in the presence of TC include:
• Cancer-related damage to the testicular cells that are responsible for the production of testosterone;
• Orchidectomy;
• Chemotherapy/RT-related damage to the remaining testicular tissue;
• Hormonal abnormalities resulting from cancer-related stress.
MetS following TC
Possible mechanisms for MetS following
TC While previous research has linked low testosterone levels with a higher fat mass, BMI and abdominal fat distribution in TC survivors, the Platinum study found that TC survivors had smaller waist circumferences in comparison to controls.
The aetiology of cancer treatment related MetS appears to differ from that in the general population, where excess calorie intake and a sedentary lifestyle are the primary causes. Cancer treatment-related MetS is multifactorial and differs between individual patients depending on their cancer diagnosis and treatment. TD and chemotherapy are thought to be the main contributors.
Conclusion
TC survivors may be at risk of various long-term treatment-related adverse effects, including TD and MetS, which can compromise health and wellbeing. TC commonly affects younger men, and with survival rates increasing, these men may suffer the effects of such chronic conditions over an extended length of time. Primary care practitioners need to be alert to the risks following TC and employ careful, regular follow-up in patients who have received treatment for this disease.
Testosterone deficiency following testicular cancer
Possible mechanisms for TD following TC
A low testosterone level may be present when TC is diagnosed, or it may follow treatment for the disease.
Causes of TD in the presence of TC include:
• Cancer-related damage to the testicular cells that are responsible for the production of testosterone;
• Orchidectomy;
• Chemotherapy/RT-related damage to the remaining testicular tissue;
• Hormonal abnormalities resulting from cancer-related stress.
MetS following TC
Possible mechanisms for MetS following
TC While previous research has linked low testosterone levels with a higher fat mass, BMI and abdominal fat distribution in TC survivors, the Platinum study found that TC survivors had smaller waist circumferences in comparison to controls.
The aetiology of cancer treatment related MetS appears to differ from that in the general population, where excess calorie intake and a sedentary lifestyle are the primary causes. Cancer treatment-related MetS is multifactorial and differs between individual patients depending on their cancer diagnosis and treatment. TD and chemotherapy are thought to be the main contributors.
Conclusion
TC survivors may be at risk of various long-term treatment-related adverse effects, including TD and MetS, which can compromise health and wellbeing. TC commonly affects younger men, and with survival rates increasing, these men may suffer the effects of such chronic conditions over an extended length of time. Primary care practitioners need to be alert to the risks following TC and employ careful, regular follow-up in patients who have received treatment for this disease.
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