I went on Arimidex 1 year ago because I was getting like freaky anxious and crazy emotional. It did help but I have been doing a lot of researching and I'm leaning towards Nelson's take on using an AI. I have been off Arimidex now for 3 months now. I did have some water gain after a few weeks but that leveled off. My anxiety was getting bad again and emotions did increase but it didn't bother me as much since I have made some adjustment to them but definitely noticeable. I decided to try Pregnenolone and DHEA. It has dramatically reduced my anxiety. I am a lot calmer. Emotion wise I would say I am just as emotional but there is a difference. I have more control over my emotions. Noticeable side effect for me are dreams. I just gave blood and my Hemo has been at a very steady 15.5 and now it's 13.8 and my BP was on average 130/80 and now 120/70. Now I know it may be unrelated so I will see if both stay low. Maybe I ate too many almonds recently ;-p. I have noticed a definite increase in my ability to focus and recall memories. Yes I know what you are going to ask. Did I test prior, no I did not. One, I know my endo won't and two it's not cheap. So I am bieng very careful and not taking that high of an amount. 50 mg DHEA twice a day and 50 Pregnenolone once in the morning. I agree with Nelson on not messing with your E unless it's really high. If you do get very anxious and you are very emotional from being on TRT I would give DHEA and Pregnenolone a shot. Just be ready to dream your ass off.