I was curious how this post would read after paragraphing same. I too was having a problem reading pretty much what amounts to 3 long paragraphs, to the extent I had to use the highlight feature to keep track of where I was while reading the post.
It's not the content of the post, just the way it was presented. Makes for a easier/better read. None of the post content was changed, except for capitalization and paragraphing below.
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OP: From reading some of your previous posts I believe you were injecting 100mg (Cypionate) every 3.5 days (200mg Cypionate/week minus the ester is 138mg testosterone). And recently you have switched to 90mg (Sustanon) every 3.5 days (180mg Sustanon/week minus the ester is roughly 135mg testosterone).
So at least we know first and foremost you are injecting roughly the same dose of testosterone weekly as eliminating this variable is critical to whether your overall weekly dose of testosterone was increased or decreased.
Have you compared overall blood work from your Cypionate injection protocol to your Sustanon protocol (total t/free t/estradiol/shbg/dht) to see if there is a difference in levels?
You say you feel much better overall using the Sustanon and no one is going to say you are not experiencing benefits due to switching from a single ester to a multi-ester.
Regarding testosterone, whether Cypionate or Sustanon (Propionate/Phenylpropionate/Isocaproate/Decanoate), once the oily depot is released from the injection site (whether faster/slower) and enters the bloodstream where the ester is cleaved off, all that is left is testosterone regardless of the ester used.
You may very well be benefiting from the various ester release rates, but as far as the effects of testosterone's actions on the AR (androgen receptor), Sustanon, let alone any multi-ester in the end is just testosterone.
As far as esters are concerned half life of the ester (length) is only one variable regarding the release of the oily depot as injection site and injection volume also play a role.
http://jpet.aspetjournals.org/content/281/1/93.long.
As far as people that "just do not speak from experience and are just trying to be an internet expert".
I disagree as there are people who have personally used different compounds whether Testosterone/AAS for either personal reasons or when manipulating different protocols for TRT with various testosterone esters. And some of these people also spend time studying the literature regarding testosterone to try and develop a better understanding of the hormone and its functions.
Regarding the pharmacology of testosterone preparations if you look over (pg.424).
You will see that regarding multi-esters. It is stated that these combinations are used following the postulate that these so called short acting testosterone ester is the effective testosterone substitution during the first days of treatment. And the so called long acting testosterone warrants effective substitution for the end of injection interval.
This assumption is not supported by the pharmacokinetic parameters of individual testosterone esters as both Propionate and Enanthate cause highest testosterone serum concentrations shortly (how many internet gurus really know that?) after injection. And that adding Propionate to Enanthate only increases the initial undesired testosterone peak and worsen the pharmacokinetic profile that ideally should follow zero order kinetics.
Finally, injection of a multi-ester produces a much wider fluctuation of testosterone serum concentrations than a single ester. In the end a single ester alone (Enanthate) produces a more favorable pharmacokinetic profile, in comparison to injections of a multi-ester (Enanthate/Propionate) in comparable doses.
And that for the treatment of male hypogonadism there is no advantage in combining the available short and long acting esters. You may very well feel better overall due to using a multi-ester combination, but is it truly due to the 4 different esters of Sustanon as you say?
Understand that there are others whom have used multi-esters and experienced the opposite of what you have. It is always good to keep an open mind and view from different perspectives.
Here is the article scroll down to page 424
https://www.researchgate.net/profile...eparations.pdf (when clicking on this link choose blue bar in upper right hand corner Download full-text PDF).
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