Supercharge Your Health: The Nitric Oxide Revolution!

madman

Super Moderator

"Meet Dr. Nathan Bryan: Nitric Oxide Pioneer & Its Impact on Human Health. Learn how nitric oxide influences vascular health, the immune system, and cardiovascular regulation. Discover the importance of maintaining nitric oxide balance for overall well-being. An eye-opening interview, exploring revolutionary insights into therapeutic strategies and disease management methods. Get ready to challenge preconceptions and embrace new health perspectives in the 21st century."


Timestamps

0:00 Intro
3:14 Nitric Oxide
5:29 Measuring Nitric Oxide “interestingly”
8:36 Oral Health and Nitric Oxide
15:02 Acid Blocking Drugs
18:00 Dietary Sources of Nitrates
19:55 Oxygen Availability
23:14 MTFHR
27:46 Age and Nitric Oxide
30:42 Viagra
35:46 Wound Healing
43:27 Latest Findings
46:27 Nathan’s Book Release
48:23 Conclusion
 
Eye-opener!

30:42-35:46


The main driver as to why some men are non-responders!

31:17-32:36

*Well it shows us that really if you can maintain blood flow then you know a lot of times you don't get this chronic dysfunction that leads to chronic disease so Viagra or what we call phosphodiesterase inhibitors are dependent upon nitric oxide production so these aren't nitric oxide generating drugs they potentiate nitric oxide so if you are able to produce a little bit of nitric oxide and then it activates an enzyme called Guanylate cyclase leads to increase in cyclic GMP and these PDE5 inhibitors prevent the breakdown of a second messenger so you can actually you know sensitize the system that is why they work for improving erectile dysfunction


*The problem is you know these drugs were approved I believe in 1998 so over 25 years on the market and you know they only work in about 40-50% of the men in which they are prescribed so these non-responders mechanistically are none responders because their bodies are not making any nitric oxide to activate the system for these drugs to work on so we can now if you restore nitric oxide you can turn non-responders into responders than the end result is vasodilation and vasodilation leads to increase in oxygen and nutrient delivery to every organ, tissue, and cell in the body
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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