Increase Nitric Oxide: Fix Blood Pressure & Inflammation Naturally

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madman

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This episode features Dr. Nathan Bryan, an expert in Nitric Oxide who specializes in reversing metabolic disease with the natural production of Nitric Oxide.

Dr Bryan has spent over 20 years researching the molecule of Nitric Oxide and it's impact on cardiovascular health as well as the prevent of chronic health conditions, namely heart attacks, strokes, dementia and Alzheimer's.

In this episode Dr Bryan discusses the two ways our body produces Nitric Oxide via the Nitric Oxide Synthase pathway and the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway. Dr Bryan explains how both Nitric Oxide pathways promote vasodilation (the widening of the arteries) and help with blood pressure regulation.

We discuss how you lose Nitric Oxide production as we age through western medicine, diet, and lifestyle factors. Dr Bryan discusses the dangers of using antiseptic mouthwash on the oral microbiome, the use of antacids and the connection to dementia, heart attacks and stroke and dietary protocols to increase Nitric Oxide production.

This episode is important for anyone who seeks to understand the cause of chronic disease, and for those who seek to optimise their heart and cardiovascular function. You will learn the science of the four hallmarks of chronic inflammation which is leading to heart attacks, stroke and dementia, the science of how Nitric Oxide prevents all chronic disease, and how to naturally increase Nitric Oxide production.





Timestamps:


00:00 Intro
03:12 What is Nitric Oxide?
04:58 Why Nitric Oxide is not in the medical mainstream
06:53 Dr Nathan Bryan's focus on Nitric Oxide
09:35 Every chronic disease is linked to a loss of Nitric Oxide
11:08 What causes the loss of Nitric Oxide as we age
14:28 How the body naturally produces Nitric Oxide: NOS Pathway
19:26 Endothelial cells vs epithelial cells
24:15 Enterosalivary pathway of Nitric Oxide
28:02 Mouthwash and the oral microbiome
31:40 Antacids and cardiovascular risk/ dementia
37:05 Nitric Oxide prevents dementia and Alzheimer's disease
38:05 Tool: Strategies to naturally increase nitric oxide
42:17 Tool: Nasal breathing
45:43 Sodium nitrite (bacon) + cancer
50:52 Tool: Dietary protocols to naturally increase Nitric Oxide
53:52 Nitric Oxide release (dumping) workout
55:28 Tool: Red light therapy
56:55 Nitric Oxide + heart attack risk
59:15 Nitric Oxide + immune system
01:03:57 Nitric Oxide to fix erectile dysfunction
01:09:29 Tool: Exogenous Nitric Oxide
01:14:55 Find Dr. Nathan Bryan
 
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Oxidative stress!




11:08-14:18 What causes the loss of Nitric Oxide as we age

*you lose Nitric Oxide production as we age through western medicine, diet, and lifestyle factors.
 
The cells ability to produce NO!




01:03:57 Nitric Oxide to fix erectile dysfunction


* increase in blood flow is dependent upon the body's ability to produce nitric oxide so if your body if you have endothelial dysfunction and you can't increase nitric oxide production then you don't get vasodilation you don't get engorgement and that's the definition of erectile dysfunction

* the non responders to PDE5 inhibition therapy are the patients who are completely devoid of any nitric oxide production so that tells us number one erectile dysfunction is a symptom of nitric oxide deficiency it's not a symptom of overactive phosphoesterase if that were the case then the pde5 inhibitors would work in 100% of the population but we know they don't so if we can restore nitric oxide production now you can take non responders or best case scenario you get these patients off these PDE5 inhibitors and stimulate activate nitric oxide production you have normal function
 

 
Oxidative stress!




11:08-14:18 What causes the loss of Nitric Oxide as we age

*you lose Nitric Oxide production as we age through western medicine, diet, and lifestyle factors.
Tetrahydrobiopterin = BH4

BH4 metabolism can instead be depicted as a cytoprotective pathway that is finely regulated by the concerted action of de novo, salvage, and recycling pathways to regulate intracellular concentrations of BH4 and BH4-related metabolites. If this finely tuned balance in BH4 concentration is perturbed, several biological systems are compromised, resulting in impaired neurotransmission, immune responses, metabolism, and vascular activity (Figure 5). Correction of the imbalance resulted in improved cell homeostasis and survival. All these imbalances can potentially be attenuated by BH4 supplementation and could be beneficial in n mitochondrial disorders. However, it should be stressed that abnormally high intracellular levels of BH4 do not promote cytoprotection. On the contrary, we have shown, in human and experimental chronic diseases, that clinical presentation is worsened when levels of BH4 surpass therapeutic or physiological levels (Figure 5). Indeed, when an inhibitor of SPR was used to normalize BH4 levels, symptoms were attenuated. Thus, BH4 metabolism can be considered a double-edge sword, with too little or too much resulting in toxicity.

IMG_1290.jpeg

Figure 5
Tetrahydrobiopterin (BH4) metabolism as a central hub regulating physiological and toxic pathways. Normal BH4 levels (green circle): Physiological levels of BH4 sustain the traditional coenzyme activity of the pathway, favoring the correct metabolism of aromatic amino acids and ether lipids, and the biosynthesis of nitric oxide. Under these conditions, appropriate BH4 levels activate energy metabolism, enhance cellular resistance to oxidative stress, modulate the inflammatory response, facilitate learning and memory, regulate immune system activity, increase vascular activity, and exert neuroprotective effects. Reduced BH4 levels (orange circle): When BH4 levels are perturbed, ATP synthesis and brain lipid signaling are impaired, an oxidant status is induced, neurotransmission is compromised, and inflammation is favored. Pathologically augmented BH4 levels (brown circle): Excessive intracellular BH4 levels induce mitochondrial dysfunction, compromise memory and learning, increase the aggressivity of the immune system, promote the progression of inflammatory and autoimmune diseases, and elicit chronic pain. Thus, BH4 metabolism can be considered a double-edged sword: too little or too much results in cytotoxicity.
 
Last edited by a moderator:
Beyond Testosterone Book by Nelson Vergel
Tetrahydrobiopterin = BH4

BH4 metabolism can instead be depicted as a cytoprotective pathway that is finely regulated by the concerted action of de novo, salvage, and recycling pathways to regulate intracellular concentrations of BH4 and BH4-related metabolites. If this finely tuned balance in BH4 concentration is perturbed, several biological systems are compromised, resulting in impaired neurotransmission, immune responses, metabolism, and vascular activity (Figure 5). Correction of the imbalance resulted in improved cell homeostasis and survival. All these imbalances can potentially be attenuated by BH4 supplementation and could be beneficial in n mitochondrial disorders. However, it should be stressed that abnormally high intracellular levels of BH4 do not promote cytoprotection. On the contrary, we have shown, in human and experimental chronic diseases, that clinical presentation is worsened when levels of BH4 surpass therapeutic or physiological levels (Figure 5). Indeed, when an inhibitor of SPR was used to normalize BH4 levels, symptoms were attenuated. Thus, BH4 metabolism can be considered a double-edge sword, with too little or too much resulting in toxicity.

View attachment 47117
Figure 5
Tetrahydrobiopterin (BH4) metabolism as a central hub regulating physiological and toxic pathways. Normal BH4 levels (green circle): Physiological levels of BH4 sustain the traditional coenzyme activity of the pathway, favoring the correct metabolism of aromatic amino acids and ether lipids, and the biosynthesis of nitric oxide. Under these conditions, appropriate BH4 levels activate energy metabolism, enhance cellular resistance to oxidative stress, modulate the inflammatory response, facilitate learning and memory, regulate immune system activity, increase vascular activity, and exert neuroprotective effects. Reduced BH4 levels (orange circle): When BH4 levels are perturbed, ATP synthesis and brain lipid signaling are impaired, an oxidant status is induced, neurotransmission is compromised, and inflammation is favored. Pathologically augmented BH4 levels (brown circle): Excessive intracellular BH4 levels induce mitochondrial dysfunction, compromise memory and learning, increase the aggressivity of the immune system, promote the progression of inflammatory and autoimmune diseases, and elicit chronic pain. Thus, BH4 metabolism can be considered a double-edged sword: too little or too much results in cytotoxicity.
Iv'e done some limited researching on this. The internet says it costs 100K a year for this. Is there a an easier way to get this?
 
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