Should I Try TRT Again?

I might have replied on your other thread, but I had some of the same issues at the beginning with a large (150mg) weekly dose. Went to every 5 days at lower dosing, but have really hit my stride at 75mg per week, divided into 3 x 25mg doses, every 2.5 days. That puts my "peak" at 900 TT and in range FT numbers. E2 has been much more manageable. Much better results for me with lower week dosing and more frequent sticks. And my SHBG is in the 40-45 range, so maybe a bit counterintuitive.
 
Ressurrecting an older thread I started over a year ago.

Like my original post says I was on TRT for nearly 4 years and had all sorts of problems. The details are laid out in the previously posts and links.

I went off TRT in November 2019, so it has been almost 2 years.

My BP, HCT, HR all returned to normal, and my sleep improved significantly. I became normal again. What is interesting is that when I retested my Test levels they were quite a bit higher than the levels I had before going on TRT.

For reference, in Sept 2020 my Total T was 505 (250-1100 ng/dl) and my Free T was 91.9 (35.0-155.0 pg/mL)

I am now almost 58 years old. In The past 6 months I've noticed that my exercise recovery is taking longer, and I am more prone to injury from my workouts. If I take a week off from lifting and jump back in, I can no longer resume at close to the same regimen I was doing before I took the break. I am also more sluggish. On the sex front my libido is lower although I have no problems in the erection department.

Basically, I'm showing the normal signs of aging. But if I can do something to turn back the clock, I'd love to try it. You guys think it is worth giving TRT another shot given the issues I had before. My initial plan is to get bloodwork done in the next month to see where my levels stand and go from there.

Any thoughts?
 
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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