Shbg

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Vettester Chris

Super Moderator
When you say "Low", what is the value on your lab?

I also have low SHBG, usually ranging 8 to 11sh, give or take. I also have some inherit genetic issues (mutation HFE2) that causes my iron & ferritin to build.

The common link in my case is the liver. In your case, you might want to explore some other labs, e.g., the items mentioned above, and also look at your metabolic profile, lipids, and hypothyroidism can even be a factor.

Again, some of it is also just relevant to what the term "Low SHBG" means? For TRT purposes, it will be good to factor how SHBG impacts free testosterone levels. As in my case, my SHBG puts my Free Test in the 3.3% for the most part. This makes a HUGE difference when looking at total serum values. A guy with 700ng/dl can have significantly more testosterone than the guy next to him, who has a 850ng/dl total serum level. This is why I stress people don't get too fixated on wanting to know what the perfect total test number is.
 
QUOTE=Vettester Chris;22944]When you say "Low", what is the value on your lab?

I also have low SHBG, usually ranging 8 to 11sh, give or take. I also have some inherit genetic issues (mutation HFE2) that causes my iron & ferritin to build.

The common link in my case is the liver. In your case, you might want to explore some other labs, e.g., the items mentioned above, and also look at your metabolic profile, lipids, and hypothyroidism can even be a factor.

Again, some of it is also just relevant to what the term "Low SHBG" means? For TRT purposes, it will be good to factor how SHBG impacts free testosterone levels. As in my case, my SHBG puts my Free Test in the 3.3% for the most part. This makes a HUGE difference when looking at total serum values. A guy with 700ng/dl can have significantly more testosterone than the guy next to him, who has a 850ng/dl total serum level. This is why I stress people don't get too fixated on wanting to know what the perfect total test number is.[/QUOTE]
 
Yes, self medicating as my GP dosn`t support it. I was pre-TRT, se calculated free testosterone 0.33 nmol.L (0.17 - 0.67) serum testosterone 12 nmol/L (7.6 - 31.4) serum albumin 45 g/L (35-50) serum sex hormone binding glob 16 nmol/L (15-64) .Just received blood work after 7 weeks on therapy - Se calculated free teastosterone 0.75nmol/L Serum Testosterone 25.3 nmol/L serum albumim 45 g/L Serum sex hormone binding glob 16nmol/L .HbA1c 34 LFT total protein 74 ALT 38 Alk.phos 45 total Bilirubin 13 Globulin 29 Oestradiol 155
 

ERO

Member
I have low SHBG as well and one of the frustrations is that one can read about all the things that may raise SHBG, like drinking green tea, more coffee, going vegan, etc...but then when you read the fine print at the end of the study, you typically find that they may raise it some very, very small percentage. Well, that is not going to be enough to help in most cases. My SHBG ranges between 7 and 14 on a scale where 20-70 is the normal range, so if (for purposes of an example) I went vegan and it raised my SHBG 10% it would still be a non-starter. I need to basically double or triple my SHBG to get it where it should be.

Another frustration is there are studies that show a correlation between low SHBG and diabetes or pre-diabetes. OK, fair enough, but I have neither of those and nobody that I know with low SHBG falls into either of those categories either. More importantly, from a mathematical/statistical standpoint, Correlation does not prove Causation. In other words, this also is not particularly useful information for many of us.
 

Vettester Chris

Super Moderator
At 16nmol, I wouldn't worry about it too much. All you can do is cover the bases and make sure it's not a marker for any metabolic or liver disorder, then manage it accordingly. Also, adjust your HRT protocol to account for higher free serum levels, so that your program is balanced.
 

CoastWatcher

Moderator
Yes, self medicating as my GP dosn`t support it. I was pre-TRT, se calculated free testosterone 0.33 nmol.L (0.17 - 0.67) serum testosterone 12 nmol/L (7.6 - 31.4) serum albumin 45 g/L (35-50) serum sex hormone binding glob 16 nmol/L (15-64) .Just received blood work after 7 weeks on therapy - Se calculated free teastosterone 0.75nmol/L Serum Testosterone 25.3 nmol/L serum albumim 45 g/L Serum sex hormone binding glob 16nmol/L .HbA1c 34 LFT total protein 74 ALT 38 Alk.phos 45 total Bilirubin 13 Globulin 29 Oestradiol 155

You wrote that you are self-administering TRT without the support of your doctor. You are drawing your own lab work, I would take it, so please be sure to pull a CBC and pay particular attention to hematocrit and hemoglobin. If they rise too high it can lead to very serious health problems.
 
You wrote that you are self-administering TRT without the support of your doctor. You are drawing your own lab work, I would take it, so please be sure to pull a CBC and pay particular attention to hematocrit and hemoglobin. If they rise too high it can lead to very serious health problems.

Thanks for your concern Clockwatcher, My GP said he cant support my TRT but will see me if I start to suffer any side effects or see where I am in 3 months. To answer your question I wont be having bloodwork as Gp dosn`t want to know and im on State Benefits for AGHD so cant afford to go private. Im basically screwed.
 
low SHBG is NOTHING to be concerned about. NOTHING. It dictates a slight difference in the frequency of your injections but as a guy that lives with it and figured it out, it's TOTALLY workable. EOD injections are typical. Think of it as how fast your body uses the T. That's not quite accurate but a good way to think of it.
 

ERO

Member
low SHBG is NOTHING to be concerned about. NOTHING. It dictates a slight difference in the frequency of your injections but as a guy that lives with it and figured it out, it's TOTALLY workable. EOD injections are typical. Think of it as how fast your body uses the T. That's not quite accurate but a good way to think of it.

It is great that you have a good working protocol, but for many of us with low SHBG, the overall feeling is basically the same as when we had Low T. I have done daily Test Prop injections, and am trying that again now, but for me the difference between Low T and being on TRT is that I don't need to take an afternoon nap now. No other benefits that one can actually feel. Everybody is different and everybody with low SHBG is different.
 
It is great that you have a good working protocol, but for many of us with low SHBG, the overall feeling is basically the same as when we had Low T. I have done daily Test Prop injections, and am trying that again now, but for me the difference between Low T and being on TRT is that I don't need to take an afternoon nap now. No other benefits that one can actually feel. Everybody is different and everybody with low SHBG is different.

Two things, with respect: 1, you're not being adequately cared for either/or T or E if your "protocol" isn't working to your satisfaction. 2, you sound as though you've given up. Maybe Thyroid, maybe Cortisol, maybe Adrenals, but I BEAT it. You can too. it's just HARDER and quite honestly, many guys don't want to commit to doing what they need to do.
 

ERO

Member
I have not given up, but I also have no issues with either T or E and I have lost count of how many thyroid and 4-tube cortisol tests I have taken over the last 5 years. (they always show no issues in either area, and yes, I have done the comprehensive thyroid tests that Gene recommends) I have worked with several respected doctors and I have been with Defy Medical for the last 6 months. None of the various protocols that are supposed to work with low SHBG guys have done anything that I can feel. I am also not diabetic, pre-diabetic, obese or lazy as I hit the weights hard 4 days a week and do cardio at least 3 days a week and have done so for years. I have tried literally every protocol available except for the pellets and the long acting Nebido, which is not yet legal in the US.

Like I say, I am very pleased that you have found a workable protocol as a guy with low SHBG. That said, as we all know, everybody is different and what works great for one person doesn't necessarily work for anyone else.
 
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