High SHGB and High a.m Testosterone with intermittent use of Nolvadex

northern2020

New Member
Greetings first time posting.

Great forum, any input appreciated.

45 year old healthy male, 4 kids

training since 12 years old, intermittent use of testosterone for training since age 35 - no more than 500mgs x 8-12 weeks 4 times over 8 years.

Recently off Testosterone as of June 2018 and but have been using Nolvadex 10-20 mgs x 3 days per week since June.

Want to start TRT

First bloodwork assessed prior to TRT eval/MD Sept 12-18

Testosterone, am 38.5 (normal range 10.3-29.5 nmol/L)

Free Testosterone 286.6 (normal 175-700 pmol/L)

SHBG 130 (normal 6-65 nmol/L)

Testosterone/SHBG = .30 (.20-1.00)

have not informed my MD of intermittent testosterone use, but wants a scan of my adrenals for a tumor, and I know this is not the case.

Question is - the nolvadex having is reducing E2, LH kinks in, has to pump more testosterone out to convert to E2 via aromatase.

I would like to start TRT - will I be declined with these labs?



Cheers
 
Last edited:
I would be concerned about your high levels of shbg.

What causes high sex hormone binding globulin in men?
  • Elevated estradiol levels from conversion of testosterone
  • Hyperthyroidism
  • Aging
  • Extreme weight loss in anorexia nervosa
  • Certain medications as the Dilantin (a phenytoin)
  • Liver cirrhosis
  • Cigarette smoking
  • Any compromise of liver detoxification such as alcohol abuse, certain meds, heavy metals etc. can decrease liver capacity to excrete excess estrogens from the body.
  • Testicular cancer
SHBG is Critical to Your Health | Natural Bio Health
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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