Sermorelin/Ipamorelin combo

rafapark

Member
Is anybody in this forum taking this combo? I have been taking the GHRP-2/Sermorelin combo from Defy for about six months with pretty good results. IGF-1 increased from 100 to 200 and has remained as such. I have lowered my body fat to 15% from 25% and increased lean muscle significantly (dexa scans). I however read in several places that GHRP-2 increases prolactin and cortisol. Both of which have increased a bit in my case. I have also read that Ipamorelin is a better GHRP vs the GHRP-2 with fewer side effects. I would like to switch to that combo but would like to hear from forum members's experiences. I am also on T (140mg a week) and HCG (500IUs twiece per week) by the way. Thanks in advance for your input.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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