Peptides: Stacking and SERMs

Varner

Member
Two primary questions:

1) Is there any benefit to stacking a GHRP with IGF-LR3?

I am trying to understand all this stuff. I'm mainly interested in the athletic performance increase aspect, as demonstrated in a few studies (GH, injected at 2mg/day, improved anaerobic capacity significantly). I know combining GHRP-6 with IGF-1 probably won't give the same level of improvement, but does the increased IGF-1 in the blood stream start a negative feedback loop and inhibit the effect of the GHRP?

(I'm thinking analogously to Clomid + testosterone injections, where the latter means the former is not doing anything)

Basically: I know stacking a GHRP and GHRH is a good idea, but what about a GHRP and IGF-1?

2) Is there any risk of pituitary damage from combining Clomid with a GHRP or GHRH? I'm already on high-dose Clomid and wonder if hitting my pituitary over and over again like that is going to render current dosages less effective in the long run.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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