Serious Low E2 Symptoms. Could Progesterone be the cause? How to lower it?

Hello,

has anyone ever used Pregnenolone with a too high dose and had side effects which could stem from high progesterone? If yes, and you stopped using it, how long till you felt better?

Is there a way to lower Progesterone,. as I believe it either lowers my e2 or blocks it from binding to receptors, so raising T dose, using some of my leftover T gel all that doesn t work to raise E2.
I also got topical E2 here but either its fake and doesnt contain any E2 or my e2 receptors are blocked cause its the second day of putting on 2-5mg woth of pure e2 on my skin and it doesnt do anything.

I guess its the 100mg pregnenolone and its conversion to progesterone that are the cause for all that.
I took the last capsule 5 days ago but I still feel like shit. How long would progesterone stay elevated and is there any way to manually lower it?


Low e2 is hell. I literally "try to get gyno". (not really but I want to raise my e2 so bad, i dont care if i overshoot the target and get high e2)

I think you are spot on as to the reason pregnenolone makes us low e2 guys feel like shit.
Everytime I try pregnenolone I feel depressed for 5 days.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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