Proven Pregnenolone supplement to raise out of range level?

blackebob

Member
My lab just came back with a mark 0f 9(22-237) for pregnenolone. I would like to be prepared to question my doctor about appropriate action. I supplement Dhea of 35mg a day, and my dhea just came back at 204(70-495). I have read you should not take the both of them, Empower info. I have no idea, no history of this, it was my first test for it. I am already looking for a Homocysteine supplement, soif anyone can help here i would appreciate it.

Thank you...
 
Pregnenlone is a poor and innaccurate test, and can be expensive (depending on one's financial perspective), reason you don't see people testing it. But test Progesterone instead as it's accurate, cost effective and a fair assumption that if Prog is OK then Preg is OK as well as it's just one step up in the conversion chain.

I don't advocate use of either one but when guys do use them, it's best for an oral micronized capsule like Empower has available, or even a TD cream. Cheap oral tablets should be avoided like the plague. Dosing on one or both should be low to judge tolerance, like 5-10mg each per day.

DHEA can be an aromatase problem in many guys.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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