madman
Super Moderator
Chapters Timeline:
4:48 Physical activity and exercise are important to make you feel better plus mental health booster
5:31 What comes to mind from the Genetics lecture?
9:24 How does liquid biopsies relate to early screening?
14:29 15-20 years ago total body CT scans not finding actionable cancer-MRI's now can
18:25 The problem of over diagnosed Prostate Cancer
19:05 Active Surveillance - why isn't every man tested for BRCA mutations?
23:16 How does being BRCA positive correlate with treatment in breast vs prostate cancer?
27:25 Random biopsies - root cause of over treatment until 2015
28:26 How does MRI replace biopsies in liver cancer? What about Prostate? PET scans?
30:53 Information is evolving too fast for one person to keep track of
31:25 GINA - Genetic Information Nondiscrimination Act 2009
32:58 Statistics show mortality rates for men with 3+3 PCa is lower than general population
34:10 Lynch Syndrome
38:05 Familial Hypercholesterolemia
39:09 Sharks and Minnows
42:52 70% of men with PSA above 4 will never get diagnosed with prostate cancer
43:41 Gadolinium contrast agent - yes or no?
44:09 MRI second opinions
48:00 MRI's can miss up to 20% of clinically significant cancers but...
49:01 Historical reason for going off active surveillance
51:02 New role for PSMA test
53:39 Around one half of men with high gleason scores will never metastasize
56:43 PSMA scans can now pick up small amounts of cancer
58:59 MRI's and PSMA scans
1:03:36 How often can MRI complement PSMA?
1:04:12 DIY Combat Manual
1:06:27 Different types of Stage 4 cancer
1:08:03 Insurance and pharmaceutical company appeals
1:12:01 Follow up - Plan B
1:15:39 Hormone resistant men with treatments from Dr. Kwon
1:17:20 Law of probability - clinical trials
1:23:11 Sharks and minnows
1:24:11 How close is a clinical trial to completion and success?
1:30:24 For some Medicare covers drugs for high cardio event risk patients
1:32:40 What are the downsides and cautions of some drugs?
1:34:39 How does lifestyle effect drugs?
1:37:25 The more you exercise the bigger the reward
1:41:39 Active surveillance patients improved with exercise - ERASE 2022 randomized trial
1:43:10 "I did all these healthy things and I still got cancer?"
1:46:27 You can benefit in a multitude of ways with exercise/taking care of yourself
1:53:01 We are cars
1:55:42 When a doctor says exercise makes a difference you should believe it
2:02:05 Diet questions
