Prostate Cancer: Bipolar Androgen Therapy (BAT)

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Summary​

Prostate Cancer Lab #56 focuses on Bipolar Androgen Therapy (BAT) as a potential treatment for castration-resistant prostate cancer. The therapy involves alternating between high-dose testosterone injections and the continuation of testosterone-suppressing drugs. BAT has shown positive results in some patients, but it may not be suitable for everyone.

Highlights​

• BAT has extended the lives of some patients and improved their quality of life.
• PSA levels may initially increase before decreasing during BAT treatment, so it is important not to panic.
• Response rates to BAT vary among patients, with approximately one-third experiencing a significant decline in PSA levels, one-third reaching a stable plateau, and one-third not responding to the therapy.
• Genetic markers such as BRCA2 and p53 mutations may predict better responses to BAT.
• The optimal timing for BAT treatment and the choice of hormone therapy are still areas of ongoing research and discussion.

 

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