Pregnenolone Blood Levels

Should we check only Progesterone or is it also important to include 17-OH progesteron when on Pregnenolone ?

I'm on 25mg oral pregnenolone before sleep, and it TRULY helps with my social anxiety .It almost killed it.
I thought that it is causing my erectile disfunction, but I did also decrease my T dose from 25mg to 20mg every day subq and after a week brain fog and ED....

I'm now again on 25mg ed subq WITH 25mg PREGNENOLONE for a week and so far everything is great, from mood to Libido. Waiting 30 days and will check hormones that Dr SAya mentioned....
 
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Should we check only Progesterone or is it also important to include 17-OH progesteron when on Pregnenolone ?

I'm on 25mg oral pregnenolone before sleep, and it TRULY helps with my social anxiety .It almost killed it.
I thought that it is causing my erectile disfunction, but I did also decrease my T dose from 25mg to 20mg every day subq and after a week brain fog and ED....

I'm now again on 25mg ed subq WITH 25mg PREGNENOLONE for a week and so far everything is great, from mood to Libido. Waiting 30 days and will check hormones that Dr SAya mentioned....
Hey Speed, still taking the pregnenolone?
 
For those of us who've tried them, the vast majority do love the results daily injections bring. Only a small number need them, but they produce results.
I recently moved to EOD and liking the results so far. Low SHBG guy. So I imagine daily would be even better.

Speed - I wonder if the pregnenolone increased your Estrogen too much? Do you have estrogen issues? I have been thinking about trying it myself so trying to get as many opinions as possible.
 
I recently moved to EOD and liking the results so far. Low SHBG guy. So I imagine daily would be even better.

Speed - I wonder if the pregnenolone increased your Estrogen too much? Do you have estrogen issues? I have been thinking about trying it myself so trying to get as many opinions as possible.

Try it. YOu have nothing to lose. If it gives you issues, just stop.
My e2 on pregnenolone was the same. It just killed my libido.... Don't know why...
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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