Please help with my protocol

Oz

New Member
I need a little help understanding my bloods please. I'm battling fatigue, irritability, anxiety, acne etc which I'm assuming are high E2 sides. I'm not using an ai and I'm pinning twice a week.
Libido improved greatly at the start of trt but has tapered off.



Labs : Free T
Range : 150-700 pmol/L
Pre TRT : 400
Test E 125mg e3.5d IM : 1281
Test E 75mg e3.5d IM : 609

Labs : Total T
Range : 10-33 nmol/L
Pre TRT : 9
Test E 125mg e3.5d IM : 42
Test E 75mg e3.5d IM : 25

Labs : SHBG
Range : 13-71 nmol/L
Pre TRT : 18
Test E 125mg e3.5d IM : 24
Test E 75mg e3.5d IM : 29

Labs : LH
Range : 1/10 iu/L
Pre TRT : 6

Labs : E2
Range : <150 pmol/l
Pre TRT : 100
Test E 125mg e3.5d IM : 250
Test E 75mg e3.5d IM : 230

Labs : Haemocrit
Range : 0.38-0.52
Pre TRT : 0.41
Test E 125mg e3.5d IM : 0.49
Test E 75mg e3.5d IM : 0.49

Labs : Prolactin
Range : <300mIU/L
Test E 125mg e3.5d IM : 282
Test E 75mg e3.5d IM : 263

Labs : DHEA
Range : 800-5700 ug/L
Pre TRT : 1800
Test E 125mg e3.5d IM : 2400
Test E 75mg e3.5d IM : 2800

Labs : T to E2 ratio
Range : Above 14
Pre TRT : 9
Test E 125mg e3.5d IM : 17
Test E 75mg e3.5d IM : 11
==============

Labs : Notes
Test E 125mg e3.5d IM : Very high E2 symptoms
Test E 75mg e3.5d IM : High E2 symptoms
 
How long were you on your 1st protocol at 125mg E3.5days and now how long have you been on 75mg every3.5days?

Lab notes indicate that these are E2 related.
Are those your notes or the doctors?
Guys tend to automatically blame estrogen for nearly everything, but I noticed you aren't on an AI.
Have you discussed any of this with your doc?
Any thyroid labs?
 
How long were you on your 1st protocol at 125mg E3.5days and now how long have you been on 75mg every3.5days?

Lab notes indicate that these are E2 related.
Are those your notes or the doctors?
Guys tend to automatically blame estrogen for nearly everything, but I noticed you aren't on an AI.
Have you discussed any of this with your doc?
Any thyroid labs?
I was on my first protocol for 7 weeks and the second for 6 weeks. These notes are my own. My doctor is not particularly on the ball so I'm doing a lot of this trial and error on my own. I was started with no ai to hopefully try and avoid using one. My interpretation is that I aromatise heavily and I may need an ai.
 
The thyroid reference ranges are not normal so normal is vague.

The evidence for a narrower thyrotropin reference range
It has become clear that previously accepted reference ranges are no longer valid as a result of both the development of more highly sensitive TSH assays and the appreciation that reference populations previously considered normal were contaminated with individuals with various degrees of thyroid dysfunction that served to increase mean TSH levels for the group. Recent laboratory guidelines from the National Academy of Clinical Biochemistry indicate that more than 95% of normal individuals have TSH levels below 2.5 mU/liter.

Reference ranges for TSH and thyroid hormones

First of all the distribution of TSH reference range is not normal, with median values (also depending on population iodine intake) usually between 1-1.5 mU/L. Though TSH remains the most commonly used endocrine test in clinical practice, the issue of an appropriate TSH, and to a lesser extent, free T4 and free T3 reference ranges is still under debate.
 
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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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