Pharmacokinetic Profile of Testosterone Suspension: A Case Study

[FunkOdyssey]

Honestly my biggest issues are penile sensitivity and poor erections. There is always a period when i restart trt where that sensitivity and those erections return and that dissipates, so i know it is definitely a hormonal issue.

Not sure what you've tried already, but I have better sensitivity and erections with test propionate than with long esters at comparable doses.

 

[StillSearching91]

Not sure what you've tried already, but I have better sensitivity and erections with test propionate than with long esters at comparable doses.

Hey - thank you for your response.

I originally always used propionate and really i didnt really feel much better on that.

One thing for sure that i know affects penis sensitivity is DHEA . When i added that, it made a lot of difference. Dave Lee talks about it a lot. My dhea-s is quite low naturally 3.2 umol/l (maybe insulin resistance - that is a cause). In order for me to get it to midrange - 7.3 umol/l - i need 50 mg , but honestly symptom wise i feel better with only 20 mg a day. 50 mg makes me feel really agitated. Maybe free dhea is actually what's more important from a symptom perspective.

I believe "Leesto" had a pretty dramatic improvement in nocturnal erections when he added in dhea.

I have only had 1 period on trt where i woke up with a massive morning erection ( September 2018) and i have literally been trying to chase and reverse engineer what i did ever since.

Here are the salient points :

• Beginning of Sep 2018, bought life extensions dhea for the first time and started taking 50mg dhea daily in the morning
• 16th Sep 2018 - Sunday Afternoon, for the first time ever i switched to test enanthate from test prop. I injected 125 mg into right glute
• 17th Sep 2018 - Monday Evening after the gym, i felt really estrogenic ( but no lab test to confirm), so out of frustration i took some arimidex ( maybe between 0.125 mg - 0.25 mg)
• Didn't do anything Tuesday or Wednesday. Ate a lot of calories and binged Wednesday night.
• Woke up Thursday from one of the deepest sleeps i have had in years and i had one of the largest and thickest erections i have had in memory and the sensitivity was there - the head of my penis was bright red just like when i was a teenager.

For the next few month - I was doing everything i could to try and recreate that.

My initial response was that - oh my testosterone finally fell into a physiological range with right ratio to estradiol. So i replicated that same 125 mg injection on a sunday, and then tested on the following Thursday to see where my test levels fell - and it was 470 ng/dl.

So i went on a mission to microdose eod to stay at those levels, but just like most guys felt nothing. There are a lot of guys who have this same experience. When that level is reached in the following days by falling from a large supraphysiologic dose, they get libido and erections, but if they microdose and titrate to hit those serum levels consistently, the effect is not the same. Maybe there is a difference at the tissue level. I dont know. I am completely lost

FYI @Cataceous - apologies for hijacking your thread - please feel free to tell me to just move to my own post if you want

 

[joikd]

This might not be the right thread for it, but would you be willing to talk about your experience using daily testosterone phenylpropionate for TRT? Despite scouring the internet, I feel like I've only seen a few reports from people who use it in that way.

I have had a lot of serious things going on in my life over the last few years, so I don't have a good baseline to compare how it felt going from TU to a TU/TA combo to TPh. No up-to-date bloodwork either. Once things settle down in my life, hopefully, I'll be able to, at least, establish what I'm feeling on TPh and get true trough and peak labs.

My reasoning for the changes were based on Cataceous's posts with the thinking that even though I can't replicate natural daily T fluctuation perfectly, I can try to get as close as I can given my situation and resources.

 

[Cataceous]

...
Honestly my biggest issues are penile sensitivity and poor erections. There is always a period when i restart trt where that sensitivity and those erections return and that dissipates, so i know it is definitely a hormonal issue.

The phenomenon is far from universal, but some subset of guys finds that too much testosterone hurts both sensitivity and erections. Additionally, short term fluctuations in serum testosterone may be more influential than we realize.

...I am not going to be using a serm, I am going to microdose arimidex to bring my estradiol below my 20 pg threshold and see if thats enough to overcome the suppression at the pitutary with gonadorelin.

This should be viable in the short-term. There are lingering questions about long-term suppression of estradiol this way. At least anastrozole has less influence in the brain than other AIs.

...
I have only had 1 period on trt where i woke up with a massive morning erection ( September 2018) and i have literally been trying to chase and reverse engineer what i did ever since.

Very common to chase those honeymoon periods. Until recently I would have said it was a fruitless endeavor. But this recent experience with TS is showing me that it pays to keep trying.

FYI @Cataceous - apologies for hijacking your thread - please feel free to tell me to just move to my own post if you want

This is minor-league hijacking compared to some of my own infractions.

 

[FunkOdyssey]

This is minor-league hijacking compared to some of my own infractions.

Minor league hijacking lol