Thanks for follow-up Cat. Why not substitute TNE oil-based for TS since the particles are dissolved?
With the caveat that this is all speculation, I think that TNE in oil is likely to have a different character. I'm guessing it is between Natesto and oral testosterone in terms of half-life. It could be viable, but might require more "fill-in" testosterone after it dissipates. That is, overnight could be problematic if natural production stays low. In contrast, the apparent two-phased nature of TS means that the larger particles are supplying a low, steady background level, while the smaller particles drive significant, short-lived post-injection spikes. I'm betting these spikes are helping to drive the good results. Perhaps the spikes somewhat mirror the natural pulsatile delivery of testosterone. I find some support in this research, which is implying fairly large transient increases in endogenous testosterone. In any case, I suspect that the short phase of TS is faster-acting than TNE in oil, due to the hydrophobic nature of the oil.
I noticed a slower CNS spike with TNE for what that is worth. Not sure if CNS spike is proxy for T spike, but TNE was noticeably slower to hit than TS.
This aligns with my speculation.
I am going to try adding Kisspeptin-10 this week to my low dose regimen of straight TE. No pulsing, just 2-3x per week bolus-style.
I'll be interested in seeing your report on this.