Permanent ED from tamoxifen?

[KovaUkko]

Hello.

So my doctor gave me tamoxifen for low t and I only took 5 pills (20mg) eod. Didn’t help with the symptoms only gave me severe loss of libido, ed and anhedonia. Then we changed to sustanon 250mg every 10 days. My doctor said symptoms of tamoxifen will go away in “couple of weeks” And I know the half life is pretty long, but now after 6 weeks off tamoxifen and 4 susta injections later my libido, ed, anhedonia have just gone gradually worse over the time. I now can’t even have erection with ed meds. I could still get hard like 2 weeks ago with cialis. It’s fucking hopeless now. No sensitivity down there whatsoever.

I have red everything I could get my hands on off this. I have red stories were people mostly get better in 2-4 weeks off serm and some stories where they get better in months. One guy who still gives me hope said it took about 6-8 months with clomid. But the thing is I just don’t understand how can this keep getting worse and worse. I feel totally castrated now, didn’t feel like this weeks ago. Total rock bottom atm. All my symptoms yell low e2 but that was normal in the blood work I had 2 weeks ago. Trt was also fine. Besides serm:s only block your e2 and not destroy it like AI as far as I know.

I will now today start injecting sustanon eod like it’s supposed to. One guy who has helped me with this also said that I should try hcg and proviron and with eod pinning they should do to the trick. No idea where to get them but if this doesn’t improve I will try to get it somewhere. I will walk to the biggest guy in the gym and ask.

I have my docs appointment in two days. Same guy who gave this shit. He was supposed to be the best there is for men’s health in my country. Didn’t tell me anything about these kind of sides that take this long (permanent?).

I know there might be hope, but every day feeling like putting I bullet to your head isn’t making this anymore easy.

Anybody know anything about this?

Maybe this is Post AI Major Dysfunction (PAMD) even tho it was serm? Would taking estradiol valerate help?

I am so fucking tired and angry.

Sorry for the rant.

 

[TLR]

I’m not saying

Hello.

So my doctor gave me tamoxifen for low t and I only took 5 pills (20mg) eod. Didn’t help with the symptoms only gave me severe loss of libido, ed and anhedonia. Then we changed to sustanon 250mg every 10 days. My doctor said symptoms of tamoxifen will go away in “couple of weeks” And I know the half life is pretty long, but now after 6 weeks off tamoxifen and 4 susta injections later my libido, ed, anhedonia have just gone gradually worse over the time. I now can’t even have erection with ed meds. I could still get hard like 2 weeks ago with cialis. It’s fucking hopeless now. No sensitivity down there whatsoever.

I have red everything I could get my hands on off this. I have red stories were people mostly get better in 2-4 weeks off serm and some stories where they get better in months. One guy who still gives me hope said it took about 6-8 months with clomid. But the thing is I just don’t understand how can this keep getting worse and worse. I feel totally castrated now, didn’t feel like this weeks ago. Total rock bottom atm. All my symptoms yell low e2 but that was normal in the blood work I had 2 weeks ago. Trt was also fine. Besides serm:s only block your e2 and not destroy it like AI as far as I know.

I will now today start injecting sustanon eod like it’s supposed to. One guy who has helped me with this also said that I should try hcg and proviron and with eod pinning they should do to the trick. No idea where to get them but if this doesn’t improve I will try to get it somewhere. I will walk to the biggest guy in the gym and ask.

I have my docs appointment in two days. Same guy who gave this shit. He was supposed to be the best there is for men’s health in my country. Didn’t tell me anything about these kind of sides that take this long (permanent?).

I know there might be hope, but every day feeling like putting I bullet to your head isn’t making this anymore easy.

Anybody know anything about this?

Maybe this is Post AI Major Dysfunction (PAMD) even tho it was serm? Would taking estradiol valerate help?

I am so fucking tired and angry.

Sorry for the rant.

I learned a long time ago not to say anything is “impossible” in this arena, but I highly doubt you have permanent ED from taking 5 tamoxifen pills. If you are just starting TRT, there is an adjustment period where everything is in flux, and no two people are the exact same when it comes to how things will affect you. My advice would be to get on a single ester of either test cyp or Enanthate, start at two injections for a total of 70 mg a week and SLOWLY titrate up.

 

[Systemlord]

Tamoxifen blocks E2 at the breast receptors only. Then you went on 250 mg Sustanon every 10 days very likely shooting your T and E2 sky high which is most likely too much, there’s the likely cause of your ED.

 

[zancek0]

Tamoxifen blocks E2 at the breast receptors only.

But if this were true then using tamoxifen wouldnt make sense in hypogonadal situations.
Also, OP is feeling suicidal. This isnt a case of despair due to ED. It's accompanying ED as a sign of low estrogenic activity (ED likely being a symptom of too high DHT in this case, not high E2, imo, especially if other symptoms are taken into account ---- with ED induced by high e2 via venous leak cialis and viagra always work).

 

[sammmy]

Your symptoms are most probably aggravated by the insane TRT regimen prescribed by your doctor.

If you had a normal free testosterone, best is to not do TRT just to "optimize" yourself - it just leads to more problems.

If you had a low free testosterone, change the TRT protocol to something more reasonable as suggested above and definitely change the doctor.

 

[Systemlord]

ED induced by high e2 via venous leak cialis and viagra always work).

Except if nitric oxide is low, which is the mechanism by which these ED drugs work.

Low, ferritin, iron will do the same.

 

[KovaUkko]

I’m not saying

I learned a long time ago not to say anything is “impossible” in this arena, but I highly doubt you have permanent ED from taking 5 tamoxifen pills. If you are just starting TRT, there is an adjustment period where everything is in flux, and no two people are the exact same when it comes to how things will affect you. My advice would be to get on a single ester of either test cyp or Enanthate, start at two injections for a total of 70 mg a week and SLOWLY titrate up.

Thank you for your reply

 

[KovaUkko]

Your symptoms are most probably aggravated by the insane TRT regimen prescribed by your doctor.

If you had a normal free testosterone, best is to not do TRT just to "optimize" yourself - it just leads to more problems.

If you had a low free testosterone, change the TRT protocol to something more reasonable as suggested above and definitely change the doctor.

Thanks for reply. I had very low t before starting anything and that was the reason I started. I will try changing the injections to small doses eod.

 

[KovaUkko]

But if this were true then using tamoxifen wouldnt make sense in hypogonadal situations.
Also, OP is feeling suicidal. This isnt a case of despair due to ED. It's accompanying ED as a sign of low estrogenic activity (ED likely being a symptom of too high DHT in this case, not high E2, imo, especially if other symptoms are taken into account ---- with ED induced by high e2 via venous leak cialis and viagra always work).

Yeah basically all the symptoms of low e match

 

[zancek0]

Except if nitric oxide is low, which is the mechanism by which these ED drugs work.

Low, ferritin, iron will do the same.

True. NO synthase is iron based enzyme so iron is crucial. Also there needs to be balance between estrogen which increases copper metabolism which increases SODs which keeps NO going via eradicating free radicals that are made when NO is synthesised. DHT is necessary to "release" NO. All NO enzyme factors also need to be available too (b1, b2, folic acid, vit C, vit E...). And also calcium is needed since eNos is calcium controlled enzyme. Everything must be in balance. If there's excess or deficiency of something NO won't work well.

 

[Gladiator]

Have you had blood tests to see if hard happening ?

 

[KovaUkko]

Have you had blood tests to see if hard happening ?

Yeah, everything looks fine. E2 and trt were both in the upper middle range.

 

[Ja05]

Hello.

So my doctor gave me tamoxifen for low t and I only took 5 pills (20mg) eod. Didn’t help with the symptoms only gave me severe loss of libido, ed and anhedonia. Then we changed to sustanon 250mg every 10 days. My doctor said symptoms of tamoxifen will go away in “couple of weeks” And I know the half life is pretty long, but now after 6 weeks off tamoxifen and 4 susta injections later my libido, ed, anhedonia have just gone gradually worse over the time. I now can’t even have erection with ed meds. I could still get hard like 2 weeks ago with cialis. It’s fucking hopeless now. No sensitivity down there whatsoever.

I have red everything I could get my hands on off this. I have red stories were people mostly get better in 2-4 weeks off serm and some stories where they get better in months. One guy who still gives me hope said it took about 6-8 months with clomid. But the thing is I just don’t understand how can this keep getting worse and worse. I feel totally castrated now, didn’t feel like this weeks ago. Total rock bottom atm. All my symptoms yell low e2 but that was normal in the blood work I had 2 weeks ago. Trt was also fine. Besides serm:s only block your e2 and not destroy it like AI as far as I know.

I will now today start injecting sustanon eod like it’s supposed to. One guy who has helped me with this also said that I should try hcg and proviron and with eod pinning they should do to the trick. No idea where to get them but if this doesn’t improve I will try to get it somewhere. I will walk to the biggest guy in the gym and ask.

I have my docs appointment in two days. Same guy who gave this shit. He was supposed to be the best there is for men’s health in my country. Didn’t tell me anything about these kind of sides that take this long (permanent?).

I know there might be hope, but every day feeling like putting I bullet to your head isn’t making this anymore easy.

Anybody know anything about this?

Maybe this is Post AI Major Dysfunction (PAMD) even tho it was serm? Would taking estradiol valerate help?

I am so fucking tired and angry.

Sorry for the rant.

Your taking sust every 10 days? It’s a multi ester so you’ll be constantly fluctuating with hormones. You need test E or test Cyp at the very least and taken minimum every 7 days. Twice a week or more to prevent further fluctuations and feeling better.

Also tamoxifen destroys my libido and causes ED, some it does and others it doesn’t but it does for me. Even after the first tablet (10mg) then as each days goes it gets worse for me personally. Tried it multiple times. Don’t take an AI or serm unless you have to. Use DIM or calcium d glucarate, or primo/mast. But you shouldn’t need anything on 250mg test a week.