Oxandrolone Decreasing Abdominal Fat

[Another Great Day]

There are a few articles describing the benefits of Oxandrolone in decreasing abdominal fat in obese 40-60 year old men.
Absolute Pharmacy stocks Oxandrolone Capsules. Would anyone know of a provider in Florida that would prescribe Oxandrolone from Absolute? Defy Medical does not use Absolute.

 

[masters2121]

There are a few articles describing the benefits of Oxandrolone in decreasing abdominal fat in obese 40-60 year old men.
Absolute Pharmacy stocks Oxandrolone Capsules. Would anyone know of a provider in Florida that would prescribe Oxandrolone from Absolute? Defy Medical does not use Absolute.

317 677 3698 text me and i will give you doc contact

 

[Jason Ellis]

Wondering about a provider myself. I use Defy for TRT needs, but I cannot do anything to lessen my belly fat, and based on my body comp, most of my belly fat is visceral versus subcutaneous. If there is a chance a low dose of Oxandrolone will reduce my belly fat (and lower my BMI of 30), I’d be ecstatic.

 

[Gman86]

Wondering about a provider myself. I use Defy for TRT needs, but I cannot do anything to lessen my belly fat, and based on my body comp, most of my belly fat is visceral versus subcutaneous. If there is a chance a low dose of Oxandrolone will reduce my belly fat (and lower my BMI of 30), I’d be ecstatic.

Why not just ask Defy if you can add low dose oxandrolone to your protocol? Empower pharmacy compounds oxandrolone. I mentioned adding it into my protocol during my last consult, at a low dose of 5-10mg/ day. I did my last consult with Mike the PA, and he said that if all my labs come back within range on my follow up labwork, most importantly my lipids, that he thinks @Dr Justin Saya MD would most likely approve adding oxandrolone to my protocol. Again, at a very low dose of 5-10mg/ day. I have been having issues with recovery, and have also been getting injured more often in the past year or two. I also have quite a bit of stubborn abdominal fat, that has been very difficult to lose, even with a proper diet and exercising regularly. Not overweight by any means. Most people look at me with clothes on and always comment that I look in shape/ skinny, but definitely have a belly going on underneath my clothes. So was looking to add oxandrolone to improve recovery, and help decrease unwanted belly fat/ possible visceral fat. I know a guy that just added it to his protocol, at only 5mg/ day, and he’s reporting that he’s seeing some really good physical changes, strength increases, and also some positives with mood and how he’s treating others around him. He said the mental benefits have been an unexpected, but welcomed benefit. He also said his libido is either unchanged or slightly increased. He reports no negatives so far, only positives. He is on week 3 of using it I believe. He will be getting labs done in a couple months to see if it is having a negative impact on his lipids/ liver enzymes. He is not with Defy btw.

 

[Gman86]

@Dr Justin Saya MD Do you have any thoughts/ experience with adding very low dose oxandrolone to some guys’ HRT protocol? Very curious to hear what you think, good or bad.

 

[swoops36]

Why not try Tesamorelin to help reduce fat? That’s what it was meant for originally, and it’s fairly easy to get these clinics to add GHRP to your protocol

 

[Jason Ellis]

Good advice. I’m always scared to ask stuff like that thinking they are going to assume I’m some sort of irresponsible moron who doesn’t much care about health but cares exclusively about body image. I have read over and over how bad visceral abdominal fat can be for one’s health. I look pretty fit, but the belly is huge and embarrassing. I can’t seem to reduce this fat for anything.

Why not just ask Defy if you can add low dose oxandrolone to your protocol? Empower pharmacy compounds oxandrolone. I mentioned adding it into my protocol during my last consult, at a low dose of 5-10mg/ day. I did my last consult with Mike the PA, and he said that if all my labs come back within range on my follow up labwork, most importantly my lipids, that he thinks @Dr Justin Saya MD would most likely approve adding oxandrolone to my protocol. Again, at a very low dose of 5-10mg/ day. I have been having issues with recovery, and have also been getting injured more often in the past year or two. I also have quite a bit of stubborn abdominal fat, that has been very difficult to lose, even with a proper diet and exercising regularly. Not overweight by any means. Most people look at me with clothes on and always comment that I look in shape/ skinny, but definitely have a belly going on underneath my clothes. So was looking to add oxandrolone to improve recovery, and help decrease unwanted belly fat/ possible visceral fat. I know a guy that just added it to his protocol, at only 5mg/ day, and he’s reporting that he’s seeing some really good physical changes, strength increases, and also some positives with mood and how he’s treating others around him. He said the mental benefits have been an unexpected, but welcomed benefit. He also said his libido is either unchanged or slightly increased. He reports no negatives so far, only positives. He is on week 3 of using it I believe. He will be getting labs done in a couple months to see if it is having a negative impact on his lipids/ liver enzymes. He is not with Defy btw.

 

[Gman86]

Why not try Tesamorelin to help reduce fat? That’s what it was meant for originally, and it’s fairly easy to get these clinics to add GHRP to your protocol

Good idea, didn’t even think of using tesa. The price is a big negative though

 

[Renman23]

Good idea, didn’t even think of using tesa. The price is a big negative though

You can find Tesamorelin at other sources. Use your discretion. I've had goo results.

 

[Gman86]

You can find Tesamorelin at other sources. Use your discretion. I've had goo results.

Any research chemical site recommendations? What site do u use? You can PM me if u don’t feel comfortable saying it here.

 

[Renman23]

Any research chemical site recommendations? What site do u use? You can PM me if u don’t feel comfortable saying it here.

I dont mind posting here. Im not affiliated with anyone so....

Ive used Bluesky with good results, and their prices are good too. I've also ordered from peptide sciences. But I havent used theirs yet... theyre my next cycle.

Buy Bulk Peptides & Liquids for Research
Tesamorelin 10mg

 

[Gman86]

I dont mind posting here. Im not affiliated with anyone so....

Ive used Bluesky with good results, and their prices are good too. I've also ordered from peptide sciences. But I havent used theirs yet... theyre my next cycle.

Buy Bulk Peptides & Liquids for Research
Tesamorelin 10mg

Ya I’ve used Peptidesciences for CJC 1295. Not sure if it did anything or not tho. I’ve heard canlabs is the best, but not sure if they have tesa. Good to know u actually saw results from bluesky tho

What dose of tesa did u take? Why did u switch to peptidesciences, just to try it and see if it’s better than bluesky?

 

[Renman23]

2mg subQ daily for 30 days . I workout at night so I inject around the belly before bedtime...
I used to get a bit of flushing after injection, but no more.
I just wanted to Try peptidesciences... looking for good sources... I was even considering buying from China.... before all this broke out.

 

[swoops36]

Good idea, didn’t even think of using tesa. The price is a big negative though

I’m waiting to hear back from my clinic on pricing for Tailor Made Tesa, either 1 or 2mg nightly. If it really is a lot I may try Bluesky

 

[swoops36]

I dont mind posting here. Im not affiliated with anyone so....

Ive used Bluesky with good results, and their prices are good too. I've also ordered from peptide sciences. But I havent used theirs yet... theyre my next cycle.

Buy Bulk Peptides & Liquids for Research
Tesamorelin 10mg

I’m not seeing Tesamorelin on Bluesky. Do they not offer it anymore?

 

[Nelson Vergel]

Oxandrolone—an oral, non-aromatizable anabolic-androgenic steroid—has repeatedly shown a modest but measurable ability to shrink visceral adipose tissue (VAT) while also trimming sub-cutaneous abdominal fat and boosting lean mass. Benefits appear rapidly (within 12 weeks), plateau at clinically low doses (20 mg day⁻¹), and linger for several months after the drug is stopped, but they come at the cost of atherogenic lipid changes and other class-specific risks. Below is a synthesis of the human data and proposed mechanisms.

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1 | Key clinical trials and what they found​

Population & design	Dose / duration	Visceral-fat outcome	Notes
32 community-dwelling men, 60-87 y (USC, double-blind RCT)	20 mg d⁻¹, 12 w	VAT ↓ 20.9 ± 12 cm² by MRI (≈ 14 %) vs. placebo (p < 0.001) academia.edu	Sub-Q abdominal fat and VAT/SAT ratio also fell; 83 % of fat loss still present 12 w post-drug. HDL-C ↓ 0.49 mmol L⁻¹.
Same cohort followed 12 w post-cycle (durability study)	20 mg d⁻¹, then off-drug 12 w	Total fat –1.5 kg and trunk fat –1.0 kg remained below baseline; lean-mass gains regressed academia.edu	Shows fat-loss persistence despite waning anabolic gains.
30 obese men, 40-60 y on hypocaloric diet (Pennington, 9-mo RCT)	10 mg bid oral oxandrolone for first 3 mo	Significantly lower visceral fat vs. testosterone enanthate or placebo at 3 mo; trend to greater VAT loss overall defymedical.comeuropepmc.org	Lipids worsened, prompting switch to nandrolone thereafter.
Resistance-training women ≥ 70 y (double-blind)	10 mg d⁻¹ + PRT, 12 w	Whole-body fat –1 kg; trunk fat ↓ 0.4 kg (NS trend) academia.edu	Illustrates smaller, still favorable trunk-fat response in older women.

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2 | Proposed mechanisms​

2.1 Direct androgen-receptor (AR) actions​

Oxandrolone has high AR affinity but cannot be aromatized. In VAT—which is AR-rich—it appears to:

• Inhibit adipogenesis and pre-adipocyte differentiation (in vitro)‏ link.springer.com
• Enhance lipolysis/lower lipoprotein-lipase activity in abdominal depots more than testosterone enanthate thinksteroids.com

2.2 Indirect metabolic effects​

• Increased insulin sensitivity (QUICKI ↑ 0.004; p = 0.018) correlated with VAT loss in the USC trial academia.edu
• Lean-mass accretion elevates resting energy expenditure, supporting negative fat balance.

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3 | Magnitude & durability of VAT loss​

• Typical decline: ~15–25 cm² (≈ 10–20 %) after 12 weeks at 20 mg d⁻¹ in older men.
• Plateau: Higher doses (40–80 mg) in HIV wasting trials give larger weight gains but proportionally similar or smaller VAT changes relative to LBM gains.
• Persistence: ≈ 60-80 % of VAT reduction remains three months post-drug, even though lean-mass gains recede. academia.edu

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4 | Safety and regulatory context​

Concern	Evidence
Atherogenic lipid shifts	LDL-C ↑, HDL-C ↓ during therapy—class effect noted in prescribing info dailymed.nlm.nih.gov
Hepatotoxicity & peliosis hepatis	Basis for FDA’s 2023 market withdrawal of oxandrolone in the USA en.wikipedia.org
Endocrine recovery	Testosterone suppression minimal; most subjects remained eugonadal post-cycle, but monitoring advised.

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5 | How oxandrolone compares to other androgens​

• Greater impact on sub-cutaneous abdominal fat and similar or slightly better VAT reduction versus intramuscular testosterone in caloric-restriction studies. defymedical.com
• Unlike aromatizable androgens, no estrogen-mediated anti-lipogenic effects—benefit is AR-dependent and depot-selective.
• At equivalent anabolic doses, oxandrolone provokes larger HDL declines than injectable testosterone, narrowing its therapeutic window. mayoclinicproceedings.org

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6 | Practical take-aways​

1. Expect modest VAT loss (~15 %) over three months at 20 mg d⁻¹ in older or obese men; effects in women and younger athletes are smaller and less studied.
2. Benefits persist longer for fat than for muscle, but lipid derangements resolve quickly once oxandrolone is stopped.
3. Clinical use is now off-label/unsupported in the U.S. following market withdrawal; any non-research use requires careful lipid, liver, and cardiovascular monitoring.
4. Lifestyle synergy matters: Protein-adequate hypo-energetic diets and resistance training amplify fat-loss and lean-mass wins, potentially permitting lower, safer doses. insidebodybuilding.com
5. Alternatives: Testosterone replacement (in hypogonadal men), GLP-1 agonists, or resistance training alone can reduce VAT without hepatotoxic risk. Weigh these options against oxandrolone’s regulatory and safety profile. biologyinsights.com

 

[Guided_by_Voices]

The net takeaway seems like more evidence that men looking to start TRT solely for gym/body composition reasons might want to consider enclomiphene/oxandrolone to start with, although at a lower dose and focused on the post-training anabolic window.

 

[Nelson Vergel]

The take away is to take enclomiphene if you want to increase muscle ? IGF-1 decreases with clomiphene or enclomiphene.

 

[Guided_by_Voices]

The take away is to take enclomiphene if you want to increase muscle ? IGF-1 decreases with clomiphene or enclomiphene.

I mention it in the context of minimizing T suppression for those who are not on anything else, similar to the protocols that combine it with oral T. I agree that Oxandrolone alone is likely a better thing to try first before jumping into TRT if gym/body comp are the primary goals.