madman
Super Moderator
* we dive deep into the myths around oral testosterone, why SHBG levels matter, how testosterone therapy affects inflammation, cardiovascular risk, cognition, libido, and longevity, and why optimizing free testosterone—not just total T—is the true goal.
In this episode, I’m joined by Shalin Shah, CEO of Marius Pharmaceuticals, to talk about the past, present, and future of testosterone replacement therapy (TRT). From the systemic decline in testosterone levels among younger men to the breakthrough FDA-approved oral testosterone Kyzatrex, this conversation explores what’s next for hormone optimization—and why it matters more than ever.
Take a look and listen as we dive deep into the myths around oral testosterone, why SHBG levels matter, how testosterone therapy affects inflammation, cardiovascular risk, cognition, libido, and longevity, and why optimizing free testosterone—not just total T—is the true goal. Plus, we discuss clinical pearls for transitioning from injections or pellets to oral therapy, monitoring labs effectively, and future directions for female testosterone replacement.Whether you’re a clinician, a patient, or someone interested in living with more energy, drive, and clarity—this episode is a must-listen.
TIMESTAMPS:
00:00 – Welcome & the testosterone crisis in men
01:00 – Meet Shalin Shah: Why testosterone is his mission
04:30 – What’s causing the testosterone collapse in younger men?
08:15 – Low T symptoms and why “normal” labs can be misleading
13:00 – Comparing TRT delivery options: injections, topicals, pellets, and oral
16:30 – Why SHBG matters more than you think
22:00 – Kyzatrex: Oral testosterone that bypasses the liver
26:00 – The importance of dietary fat for oral testosterone absorption
33:00 – Estrogen management and why most men don’t need AIs
38:00 – TRT and fertility: What the Kyzatrex trials reveal
41:00 – How to transition from other TRT forms to oral
43:00 – Best practices for lab testing Kyzatrex
44:30 – How testosterone affects inflammation, cardiovascular risk & longevity
46:00 – Future of TRT for women
48:00 – What Shalin would tell his younger self
49:00 – Where to learn more about Kyzatrex, Marius, and TRT science
In this episode, I’m joined by Shalin Shah, CEO of Marius Pharmaceuticals, to talk about the past, present, and future of testosterone replacement therapy (TRT). From the systemic decline in testosterone levels among younger men to the breakthrough FDA-approved oral testosterone Kyzatrex, this conversation explores what’s next for hormone optimization—and why it matters more than ever.
Take a look and listen as we dive deep into the myths around oral testosterone, why SHBG levels matter, how testosterone therapy affects inflammation, cardiovascular risk, cognition, libido, and longevity, and why optimizing free testosterone—not just total T—is the true goal. Plus, we discuss clinical pearls for transitioning from injections or pellets to oral therapy, monitoring labs effectively, and future directions for female testosterone replacement.Whether you’re a clinician, a patient, or someone interested in living with more energy, drive, and clarity—this episode is a must-listen.
TIMESTAMPS:00:00 – Welcome & the testosterone crisis in men
01:00 – Meet Shalin Shah: Why testosterone is his mission
04:30 – What’s causing the testosterone collapse in younger men?
08:15 – Low T symptoms and why “normal” labs can be misleading
13:00 – Comparing TRT delivery options: injections, topicals, pellets, and oral
16:30 – Why SHBG matters more than you think
22:00 – Kyzatrex: Oral testosterone that bypasses the liver
26:00 – The importance of dietary fat for oral testosterone absorption
33:00 – Estrogen management and why most men don’t need AIs
38:00 – TRT and fertility: What the Kyzatrex trials reveal
41:00 – How to transition from other TRT forms to oral
43:00 – Best practices for lab testing Kyzatrex
44:30 – How testosterone affects inflammation, cardiovascular risk & longevity
46:00 – Future of TRT for women
48:00 – What Shalin would tell his younger self
49:00 – Where to learn more about Kyzatrex, Marius, and TRT science
