New Weight Loss Drug: Wegovy

madman

Super Moderator

Martin Miner, MD, is the co-director of the Men’s Health Center at The Miriam Hospital in Providence, Rhode Island, and a clinical professor of family medicine and urology at Brown University. Here, PCRI's resident moderator, Mark Moyad, MD, MPH, asks Dr. Miner about "semaglutide," a medication used to facilitate weight loss. He asks if it is really the game-changer it is hyped up to be and how it compares to weight loss medications that have been used in the past and even presently.
 
Martin Miner:

*this is the only drug when I was going through in the talk though you saw those changes in obesity in these placebo-controlled trials after one year was less than 6% with bariatric surgery you can achieve between 15 and 18% weight loss of body mass over a year to a year and a half with these medications you can now achieve that same weight loss as bariatric surgery with the medication and maintain it
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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