I'll reiterate my hypothesis that there's no single level of estradiol that's optimal for everything, even in a single individual. So one level might be optimal for body composition, another level better for sexual function, yet another level better for libido, etc. And what about emotional responsiveness? That was a side effect I really noticed with estradiol in the 50s pg/mL. It was interesting and novel for a while, but eventually I didn't like it so much. I can't imagine what that would be like with estradiol closer to 100. Yet supposedly guys are supplementing to achieve that?
And this may be nothing, but in
this paper there is discussion of the possibility of different and even opposite effects of estradiol on vasculature between males and females. In the worst case, what if it's protective of women but harmful to men? It's speculative, but it would be good to know more.