Need simple explanation about the effects of Cucurmin on Testosterone Synthesis

[kanishen18]

I got this from examine.com and I need someone to make it easier for me to understand. I believe cucurmin did some suppression to my LH secretion.

If so, how do we reverse this effect? Or when can I get this tested.

11Interactions with Hormones
11.1Testosterone
Curcumin, at 100mg/kg bodyweight in rats, has been shown to preserve testosterone levels when coadministered with a drug (Metronidazole) that causes testosterone reductions and worsens parameters of sperm.[183] Protective effects on the testes have also been noted with curcumin in regards to alcohol, where curcumin (80mg/kg bodyweight) was able to preserve testicle structure and testosterone levels despite alcohol consumption,[184] most likely though preventing the oxidation of ethanol to acetylaldehyde.[185] Other compounds that damage the testicles and reduce testosterone, but are protected against by curcumin, include excessive chromium levels[186] and cadmium.[187] When looking at the 17beta-HSD3, the final step in testicular testosterone synthesis, curcumin was found to be a noncompetitive inhibitor with an IC50 of 2.3uM, and brought Luteinizing-Hormone stimulated testosterone levels down to 34% of control at a concentration of 10uM.[37] This effect was not dose-dependent, and concentrations of 1uM were not significantly different from 0.1uM and control cells.[37] Curcumin may also possess inhibitory actions against 5-alpha reductase, the enzyme that converts testosterone into the more potent androgen DHT. The IC50 value is reportedly between 5-10uM.[38] Given the above two mechanisms (17beta-HSD3 and 5AR inhibition) are anti-androgenic in nature, it would be prudent to observe in vivo effects of curcumin. The only current study on the matter used injections of PEG-curcumin at 0.5mg (giving a Cmax of 7ug/mL to then decline to 1ug/mL) noted a decrease in circulating testosterone levels and function of seminal vesicles, although testicle weight did not decline.[188] In regards to aromatase, the enzyme that converts testosterone to estrogen (and thus higher activity would mean a more anti-androgenic profile), curcumin does not directly inhibit aromatase in vitro[189] but appears to reduce the catalytic activity of aromatase (also known as CYP1A) in mice.[190] Clinical relevance of these effects is not known.

 

[Cataceous]

The suppression is not of LH, but of testosterone created by Leydig cells in the presence of LH. The effect was only observed at the highest concentration. The underlying reference notes "Human studies indicate that curcumin is tolerated in large oral doses, as high as to 8000 mg/day, without apparent toxicity. Whether the inhibition of 17b-HSD3 can be achieved under normal dietary consumption requires further investigation."

It seems unlikely that you consumed enough curcumin to activate these effects. What was your daily dose?

 

[Nelson Vergel]

I would not hold my breath on this one.

 

[kanishen18]

The suppression is not of LH, but of testosterone created by Leydig cells in the presence of LH. The effect was only observed at the highest concentration. The underlying reference notes "Human studies indicate that curcumin is tolerated in large oral doses, as high as to 8000 mg/day, without apparent toxicity. Whether the inhibition of 17b-HSD3 can be achieved under normal dietary consumption requires further investigation."

It seems unlikely that you consumed enough curcumin to activate these effects. What was your daily dose?

800mg.

 

[Cataceous]

800mg.

I would not worry about taking this much.