kanishen18
New Member
I got this from examine.com and I need someone to make it easier for me to understand. I believe cucurmin did some suppression to my LH secretion.
If so, how do we reverse this effect? Or when can I get this tested.
11Interactions with Hormones
11.1Testosterone
Curcumin, at 100mg/kg bodyweight in rats, has been shown to preserve testosterone levels when coadministered with a drug (Metronidazole) that causes testosterone reductions and worsens parameters of sperm.[183] Protective effects on the testes have also been noted with curcumin in regards to alcohol, where curcumin (80mg/kg bodyweight) was able to preserve testicle structure and testosterone levels despite alcohol consumption,[184] most likely though preventing the oxidation of ethanol to acetylaldehyde.[185] Other compounds that damage the testicles and reduce testosterone, but are protected against by curcumin, include excessive chromium levels[186] and cadmium.[187] When looking at the 17beta-HSD3, the final step in testicular testosterone synthesis, curcumin was found to be a noncompetitive inhibitor with an IC50 of 2.3uM, and brought Luteinizing-Hormone stimulated testosterone levels down to 34% of control at a concentration of 10uM.[37] This effect was not dose-dependent, and concentrations of 1uM were not significantly different from 0.1uM and control cells.[37] Curcumin may also possess inhibitory actions against 5-alpha reductase, the enzyme that converts testosterone into the more potent androgen DHT. The IC50 value is reportedly between 5-10uM.[38] Given the above two mechanisms (17beta-HSD3 and 5AR inhibition) are anti-androgenic in nature, it would be prudent to observe in vivo effects of curcumin. The only current study on the matter used injections of PEG-curcumin at 0.5mg (giving a Cmax of 7ug/mL to then decline to 1ug/mL) noted a decrease in circulating testosterone levels and function of seminal vesicles, although testicle weight did not decline.[188] In regards to aromatase, the enzyme that converts testosterone to estrogen (and thus higher activity would mean a more anti-androgenic profile), curcumin does not directly inhibit aromatase in vitro[189] but appears to reduce the catalytic activity of aromatase (also known as CYP1A) in mice.[190] Clinical relevance of these effects is not known.
If so, how do we reverse this effect? Or when can I get this tested.
11Interactions with Hormones
11.1Testosterone
Curcumin, at 100mg/kg bodyweight in rats, has been shown to preserve testosterone levels when coadministered with a drug (Metronidazole) that causes testosterone reductions and worsens parameters of sperm.[183] Protective effects on the testes have also been noted with curcumin in regards to alcohol, where curcumin (80mg/kg bodyweight) was able to preserve testicle structure and testosterone levels despite alcohol consumption,[184] most likely though preventing the oxidation of ethanol to acetylaldehyde.[185] Other compounds that damage the testicles and reduce testosterone, but are protected against by curcumin, include excessive chromium levels[186] and cadmium.[187] When looking at the 17beta-HSD3, the final step in testicular testosterone synthesis, curcumin was found to be a noncompetitive inhibitor with an IC50 of 2.3uM, and brought Luteinizing-Hormone stimulated testosterone levels down to 34% of control at a concentration of 10uM.[37] This effect was not dose-dependent, and concentrations of 1uM were not significantly different from 0.1uM and control cells.[37] Curcumin may also possess inhibitory actions against 5-alpha reductase, the enzyme that converts testosterone into the more potent androgen DHT. The IC50 value is reportedly between 5-10uM.[38] Given the above two mechanisms (17beta-HSD3 and 5AR inhibition) are anti-androgenic in nature, it would be prudent to observe in vivo effects of curcumin. The only current study on the matter used injections of PEG-curcumin at 0.5mg (giving a Cmax of 7ug/mL to then decline to 1ug/mL) noted a decrease in circulating testosterone levels and function of seminal vesicles, although testicle weight did not decline.[188] In regards to aromatase, the enzyme that converts testosterone to estrogen (and thus higher activity would mean a more anti-androgenic profile), curcumin does not directly inhibit aromatase in vitro[189] but appears to reduce the catalytic activity of aromatase (also known as CYP1A) in mice.[190] Clinical relevance of these effects is not known.
