Can Testosterone Therapy HELP Prostate Cancer?

madman

Super Moderator

In this episode, Dr. Brandon & Dr. Morgentaler talk about the emerging evidence that testosterone therapy may be safe—and even beneficial—for men with metastatic prostate cancer.




Chapters

00:11 – Testosterone Use in Metastatic Prostate Cancer


Dr. Morgentaler introduces the surprising evidence that testosterone may not be harmful in metastatic prostate cancer, and Dr. Brandon sets the stage for the discussion.


00:49 – Historical Perspective on Androgen Deprivation

Dr. Morgentaler explains the 80-year history of lowering testosterone as standard treatment and why its benefits have been overstated.


03:59 – Challenging the Norm: Testosterone Treatment Cases

Dr. Morgentaler shares real patients he treated with testosterone—supported by Dr. Brandon—with outcomes that contradict the belief that testosterone accelerates cancer.

10:09 – Modified BAT: A New Approach

Dr. Morgentaler describes his “modified BAT” cycling strategy for advanced cancer, while Dr. Brandon reflects on the quality-of-life implications.


17:40 – Conclusion and Future Directions

Both Dr. Brandon and Dr. Morgentaler call for new trials and highlight how modern evidence challenges the fear that testosterone fuels cancer.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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