Natural: why is my test so high?

[Dasein88]

I am 40 years old. I am natural. I recently, I had my total and free testosterone checked, because I suspected it was going to be low. However, it’s actually at the high end of normal. Before anyone asks, no, I haven’t had any other tests related to hormones performed. Is there anything you can tell me about why my testosterone would be so high?

 

[WhiteMale]

You're healthy in that way.

 

[Vince]

I am 40 years old. I am natural. I recently, I had my total and free testosterone checked, because I suspected it was going to be low. However, it’s actually at the high end of normal. Before anyone asks, no, I haven’t had any other tests related to hormones performed. Is there anything you can tell me about why my testosterone would be so high?


View attachment 54253

One of my buddies who's in his '60s had his testosterone check because he was tired. He's type 2 diabetic, on blood pressure meds and he's total T is just over a thousand. Not bad for an old man. He did not have his free T checked.

 

[madman]

I am 40 years old. I am natural. I recently, I had my total and free testosterone checked, because I suspected it was going to be low. However, it’s actually at the high end of normal. Before anyone asks, no, I haven’t had any other tests related to hormones performed. Is there anything you can tell me about why my testosterone would be so high?


View attachment 54253

Although TT is important to know it means nothing when looking at the bigger picture here.

The critical fraction that truly matters is free testosterone.

Those natty males running around with high/very high TT have high SHBG.

Even though your TT is high your FT is not very high as you are hitting a FT 13.4 ng/dL (Quest ED assay) which is just above where a healthy young natty male would sit tested using the most accurate assay the gold standard Equilibrium Dialysis.

Your FT is healthy not high.

Most ED assays use a reference range 5-21/5-28 ng/dL whereas Quests top-end is 15.5 ng/dL.

When tested using a state of the art standardized ED assay/procedure with a reference range 5-25 ng/dL most natty healthy young males. would be hitting a FT 12 ng/dL.

FT <5 ng/dL would be considerd low.

FT 5-9 ng/dL would be considered the grey zone where some men MAY experience symptoms of low-T.

FT 10-15 ng/dL would be healthy.

FT 20-25 ng/dL would be high-end/high!


*Assays that are standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods. Results obtained using standardized methods can be compared across assays, institutions, populations, and past and future test results, thereby improving diagnosis, treatment, and outcomes of patients

Thread 'Age-stratified reference ranges for directly measured (ED LC-MS/MS) serum free testosterone in healthy men'

May 11, 2024

Just to be clear up any confusion this is Fiers camps data for mFT reference ranges not the harmonized reference range being worked on by the CDC.


*Serum samples were analyzed from healthy men participating in the SIBLOS/SIBEX and EMAS studies, both population-based cohort studies

* mFT levels were measured in 867 men using ED LC-MS/MS as previously reported (1). Subsequently, 95% reference ranges were determined using the non-parametric method


Reference: 1. Fiers T, Wu F, Moghetti P, Vanderschueren D, Lapauw B, Kaufman JM. Reassessing Free-Testosterone...

• madman
• free testosterone; ed/refernce range; tth
• Replies: 9
• Forum: Testosterone and Men's Health Articles

*We established mFT reference ranges for healthy men aged 18 to 69 years




We present 95% mFT age-stratified reference ranges

Age category (years)	Median mFT (ng/dl)	95% mFT reference range (ng/dl)
18-29 (n=140) 30-39 (n=252)	12.0 9.8	6.7-25.3 4.9-18.5
40-49 (n=207)	8.1	4.3.14.2
50-59 (n=146)	7.1	3.8-12.8
60-69 (n=126)	6.4	3.4-11.7
70-79 (n=125)	5.6	2.7-8.7

*The gold-standard for the determination of FT levels is considered to be directly measured free testosterone (mFT) using equilibrium dialysis followed by mass spectrometry (ED LC-MS/MS). However, no widely accepted reference ranges are available for this clinical parameter. We established mFT reference ranges for healthy men aged 18 to 69 years




*Serum samples were analyzed from healthy men participating in the SIBLOS/SIBEX and EMAS studies, both population-based cohort studies


* mFT levels were measured in 867 men using ED LC-MS/MS as previously reported (1).


Reference: 1. Fiers T, Wu F, Moghetti P, Vanderschueren D, Lapauw B, Kaufman JM. Reassessing Free-Testosterone Calculation by Liquid Chromatography–Tandem Mass Spectrometry Direct Equilibrium Dialysis. J Clin Endocrinol Metab. 2018;103(6). doi:10.1210/jc.2017-02360

Reassessing Free-Testosterone Calculation by Liquid Chromatography–Tandem Mass Spectrometry Direct Equilibrium Dialysis

Reassessment of FT in women and men with state-of-the-art methodology confirms previously established FT percentages but highlights limitations of differen

academic.oup.com

In the current study, we used a state-of-the-art direct ED method to reassess FT in sets of representative serum samples. This method takes advantage of the ability of a highly sensitive and accurate measurement of T by liquid chromatography–tandem mass spectrometry (LC-MS/MS) to reliably measure the low FT concentration directly in the dialysate after ED. This more straightforward method avoids potential sources of inaccuracy in indirect ED, such as those resulting from tracer impurities or from measures to limit their impact (e.g., sample dilution). We then used the measured FT results to re-evaluate some characteristics of two more established and a more recently proposed calculations for estimation of FT.

 

[madman]

One of my buddies who's in his '60s had his testosterone check because he was tired. He's type 2 diabetic, on blood pressure meds and he's total T is just over a thousand. Not bad for an old man. He did not have his free T checked.

he's total T is just over a thousand. Not bad for an old man. He did not have his free T checked.

Not bad for an old man would only hold weight if his FT was healthy.

TT means nothing without knowing where the critical fraction sits.

 

[Vince]

he's total T is just over a thousand. Not bad for an old man. He did not have his free T checked.

Not bad for an old man would only hold weight if his FT was healthy.

TT means nothing without knowing where the critical fraction sits.

Now that he is off of 3th shift. He's no longer tired. So I'm sure he won't get his levels checked again.

 

[BadassBlues]

Amazing to me that after all these years, and all of the trips through the weeds and the deep dives down the rabbit hole that we still need to remind people that the only true meaningful measurement of testosterone is free testosterone.

Take that a step further and measure total and free DHT and then you have an accurate picture.

DHT Free

Free, active DHT in blood.

emmo.ai

What is DHT Free?​

DHT Free is a potent androgen derived from testosterone. It is primarily responsible for the development of male secondary sexual characteristics, such as facial hair and a deeper voice. In women, DHT is involved in maintaining muscle mass and bone density. Unlike total DHT, which includes both bound and unbound forms, DHT Free refers specifically to the unbound, active form that is readily available to tissues.

A healthy level of free DHT is also beneficial in balancing out any estrogen issues.

 

[Vince]

Amazing to me that after all these years, and all of the trips through the weeds and the deep dives down the rabbit hole that we still need to remind people that the only true meaningful measurement of testosterone is free testosterone.

Take that a step further and measure total and free DHT and then you have an accurate picture.

DHT Free

Free, active DHT in blood.

emmo.ai

What is DHT Free?​

DHT Free is a potent androgen derived from testosterone. It is primarily responsible for the development of male secondary sexual characteristics, such as facial hair and a deeper voice. In women, DHT is involved in maintaining muscle mass and bone density. Unlike total DHT, which includes both bound and unbound forms, DHT Free refers specifically to the unbound, active form that is readily available to tissues.

A healthy level of free DHT is also beneficial in balancing out any estrogen issues.

Of course some men need very little testing or Labs because they feel good. Others for whatever reason never feel good no matter how many times they adjust their protocol.

That was like me with tendonitis in my Achilles tendon I tried acupuncture, therapy, a chiropractor and compression bags. Nothing worked until I found creatine for some reason that cured it.

Thread 'Results from my ultrasound of right Achilles tendon.'

Nov 18, 2022

If anyone has dealt with this or has information on healing, it. I would appreciate it.

IMPRESSION: Findings suggestive of chronic tendinosis with subtle partial
tearing involving the deep tendon fibers of the mid Achilles tendon, as
above.

Narrative​

ULTRASOUND RIGHT ACHILLES TENDON DATED 11/18/2022.

HISTORY: Pain with movement and while sitting for 3 months.

COMPARISON: None.

FINDINGS: The Achilles tendon is thickened with heterogeneity and slightly
decreased echogenicity of its deep fibers within the mid Achilles tendon.
Findings suggestive of tendinosis. Partial tearing of...

• Vince
• achilles tendon.
• Replies: 22
• Forum: Health & Wellness