NAD+

Let us know how it goes mate. I'm doing 500mg of Nicotinamide for some time now with my shake and feels good. I might give the OG Niacin a try as from reading that is what gave the most benefits to people in regards to energy/metabolism. But also my shake has other compounds so its hard to tell which moving part does what but idgaf as long as i'm feeling good and even getting better every week. Energy/vitality/libido/eq been great lately without TRT even though I do miss it sometimes hehe.
 
This is what I ordered:


1000 mg for 119.00. It also comes in a large vial that holds 5 ml of bac water, no need to transfer to a bigger vial.
 
Absolutely no doubt as to the mood enhancing properties. I have been chirping for days and feel great. The energy aspect is there as well, but it could just be the mood elevation.

This isn't something that just works on demand, so I am assuming that after 6-8 weeks of regular use the benefits will be more noticeable.
How much have u injected so far?

And how much of the oral Nicotinamide Riboside are u taking? And what brand are u using?

Just injected 50mg for the first time this morning. Plan on doing 50mg 3x/ week I think.

Also, I’ve been going back and forth on what dose of selegiline to take, and how to take it. But I think I’ve settled on taking it orally. Are u still taking 5mg of selegiline orally per day?
 
How much have u injected so far?

And how much of the oral Nicotinamide Riboside are u taking? And what brand are u using?

Just injected 50mg for the first time this morning. Plan on doing 50mg 3x/ week I think.

Also, I’ve been going back and forth on what dose of selegiline to take, and how to take it. But I think I’ve settled on taking it orally. Are u still taking 5mg of selegiline orally per day?
I have been doing 50 mg EOD so far. I am going to up that to 100 mg starting tomorrow. I'm 68, so I require a higher dose to achieve the results I am looking for. After a few months, I plan on getting the IV treatment to see how that feels.

If you look at the ingredients to the original NR product made by Elysium (Basis), it includes their own proprietary NR-E at 250 mg, which is essentially just NR with a fancy name for marketing. They also combine pterostilbene at 50 mg. pterostilbene is similar, but more powerful than resveratrol. A 30 day supply is 60.00. The next top rated product is Tru Niagen which has NR Chloride at 300 mg. and no pterostilbene. That product sells for 40.00 for a 30 day supply. So knowing what ingredients to look for allows you to go shopping for a comparable product that hasn't spent a ton of money on marketing, so they can sell the product at a cheaper price. The tricky part is avoiding the garbage. I found this product:


Ingredients are 1500 mg of NR, plus 200 mg of pterostilbene and TMG. 2 month supply at 2000 mg. is 40.00. They also have a higher amount in the dosage. You could split the dose and just take a single pill and have a 60 day supply. NR is not an expensive item, so there is no reason that they wouldn't be selling a legit product (in theory).

It's interesting you bring up Selegiline. This is another supplement / medication that is age related. I still take 5 mg a day. But a younger person could take less and even split the dosing to EOD or twice a week to see benefits. 2 mg for someone under 40 EOD would likely be a great protocol.
 
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@BadassBlues
Wow, amazing reply!! Thanks so much for going into so much detail. I’ll most likely grab that that NR supplement that u linked. $40 seems like a pretty damn good price for what ur getting

What does the tmg do, and why is it added to this specific product? Does it enhance the NR’s effects somehow?

Ya I’m gonna start low and titrate up as needed with the selegiline. Currently taking 1.25mg orally per day. Just turned 39. Will see how this goes for like a month, and then titrate up to 2.5mg orally per day if needed. And then will continue to titrate up, again, if needed. I’ve been taking selegiline for years now. Kind of off and on. But more on the last year or two. Always took it sublingually, and just a little worried about reaching moa-a inhibition territory with the sublingual. I want as little increase in my serotonin levels as possible. Only looking for an increase in dopamine, and the other catecholomines that come with mao-b inhibition. For reference, been mostly doing 1.25mg sublingually EOD or E3D for a long time prior to switching to taking it orally about a couple days ago
 
@BadassBlues
Wow, amazing reply!! Thanks so much for going into so much detail. I’ll most likely grab that that NR supplement that u linked. $40 seems like a pretty damn good price for what ur getting

What does the tmg do, and why is it added to this specific product? Does it enhance the NR’s effects somehow?

Ya I’m gonna start low and titrate up as needed with the selegiline. Currently taking 1.25mg orally per day. Just turned 39. Will see how this goes for like a month, and then titrate up to 2.5mg orally per day if needed. And then will continue to titrate up, again, if needed. I’ve been taking selegiline for years now. Kind of off and on. But more on the last year or two. Always took it sublingually, and just a little worried about reaching moa-a inhibition territory with the sublingual. I want as little increase in my serotonin levels as possible. Only looking for an increase in dopamine, and the other catecholomines that come with mao-b inhibition. For reference, been mostly doing 1.25mg sublingually EOD or E3D for a long time prior to switching to taking it orally about a couple days ag


 
Thanks for the link. Will check it out now

Was just researching the NR product u take, and came across a couple things that seem slightly concerning. Not sure how much weight to put into either, but just thought I’d at least share what I came across. One was a review I read when checking the reviews of the product u linked, and then the other is a Reddit thread I came across

Reviewer on Amazon
-Consumer lab recently tested a number of Nicotinamide Riboside brands and it turned out that there are many, sold on Amazon and elsewhere, containing absolutely no NR. Orgabay, Nesticum, and Aquifoly are all the same product, and one was named in that category, I believe it was Orgabay. So I emailed the owner and asked why they didn’t show a copy of their third party testing, and the answer was “we’re working on it.” So be aware that it’s cheap for a reason. There’s no NR in it.



 
Thanks for the link. Will check it out now

Was just researching the NR product u take, and came across a couple things that seem slightly concerning. Not sure how much weight to put into either, but just thought I’d at least share what I came across. One was a review I read when checking the reviews of the product u linked, and then the other is a Reddit thread I came across

Reviewer on Amazon
-Consumer lab recently tested a number of Nicotinamide Riboside brands and it turned out that there are many, sold on Amazon and elsewhere, containing absolutely no NR. Orgabay, Nesticum, and Aquifoly are all the same product, and one was named in that category, I believe it was Orgabay. So I emailed the owner and asked why they didn’t show a copy of their third party testing, and the answer was “we’re working on it.” So be aware that it’s cheap for a reason. There’s no NR in it.



Good to know.
 
Thanks to Gman's sleuthing, it appears that the Orgabay product is bunk. It's a damn shame that there is so much dishonesty in the supplement market. I assumed that the product may have less of the active ingredients than advertised as that is common. But according to testing done, it has none. From Consumer Labs:

"The following 14 products had less than 1% of label claim, Aesticum liposomal 2,000 mg, Aquifoly liposomal 1500 mg, Cellulim 500 mg, Eterna, GriMed, Happy Aging, High Quality, inGreens, Neurogan drops, Neurogan gummies, Orgabay liposomal, Rokit America, Shizam gummies, and Vantein liposomal.

I am going to leave a review on Amazon and demand a refund.

The top NR products are Life Extension, Thorne and Tru Niagen.

*** UPDATE*** Product refunded.

I decided on the Life Extension product, best bang for the buck:

 
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Thanks to Gman's sleuthing, it appears that the Orgabay product is bunk. It's a damn shame that there is so much dishonesty in the supplement market. I assumed that the product may have less of the active ingredients than advertised as that is common. But according to testing done, it has none. From Consumer Labs:

"The following 14 products had less than 1% of label claim, Aesticum liposomal 2,000 mg, Aquifoly liposomal 1500 mg, Cellulim 500 mg, Eterna, GriMed, Happy Aging, High Quality, inGreens, Neurogan drops, Neurogan gummies, Orgabay liposomal, Rokit America, Shizam gummies, and Vantein liposomal.

I am going to leave a review on Amazon and demand a refund.

The top NR products are Life Extension, Thorne and Tru Niagen.

*** UPDATE*** Product refunded.

I decided on the Life Extension product, best bang for the buck:

How were u able to see the consumer labs reports? Are u a paying member?

Did consumer labs find that the life extension version had what it was supposed to have in it? Is that why u chose that one specifically?

And although the product u were taking was bunk, we now know that the positive mood improvements u’ve been experiencing were mostly due to the injectable NAD+. Which is good to know, since I was personally wondering how much of the improvements were coming from the injectable NAD+, and how much were coming from the oral NR product u were taking. So if someone did want to decide to do only one or the other, maybe due to financial reasons, it looks like the injectable NAD+ might be the better option. Just speculating obviously. But that’s at least the pro that I’m taking away from this lol. But glad to see that u were able to get a refund
 
How were u able to see the consumer labs reports? Are u a paying member?

Did consumer labs find that the life extension version had what it was supposed to have in it? Is that why u chose that one specifically?

And although the product u were taking was bunk, we now know that the positive mood improvements u’ve been experiencing were mostly due to the injectable NAD+. Which is good to know, since I was personally wondering how much of the improvements were coming from the injectable NAD+, and how much were coming from the oral NR product u were taking. So if someone did want to decide to do only one or the other, maybe due to financial reasons, it looks like the injectable NAD+ might be the better option. Just speculating obviously. But that’s at least the pro that I’m taking away from this lol. But glad to see that u were able to get a refund
I joined today. I was unaware they existed until your post. I would recommend anyone who is a supplement buyer join. Its 69.00 a year, well worth it. Had I have been a member earlier; I could likely have saved a bundle on some of the supps I have purchased that turned out to be junk.

The NAD+ injections offer very fast results as it's pure NAD+, so yes... that is most definitely the best option. Oral precursors take weeks to months to see any benefits. I just think it's a good idea to do both.

As to the top product, Life Extension and Tru Niagen both have the same form of Niagen @ 300 mg. The LE product is 10 dollars cheaper.
 
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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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