My Ongoing TRT Mystery

OP, regarding anxiety, you might want to check out the book Adrenal Dominance by Dr. Michael Platt. He believes high adrenalin is one of the root causes of anxiety. There is also a podcast with him and Dave Asprey on Dave's site which you can easily search for where he describes his approach. I think it is around #610 or so. He recommends a small dose of progesterone to counteract adrenalin. It's not mentioned in the podcast but progesterone for men can cause libido issues if you go too high so you definitely would want to start low, but what he says may help you. Good luck. I am praying for you.
Thanks man. I got his book and read it today, I also emailed him. I’ve never tried prog so this could be a big help. His descriptions also seem to fit my issues.

Are you a fan of the band GBV?
 
I feel nauseous, dehydration, diarrhea, fatigue, weakness, rapid, heart rate, and trouble breathing.

I’ve heard someone on YouTube say that you can have a gene defect that makes you hyper sensitive to vitamin D.
I saw that too, I believe it’s the CYP24a1. Sadly my dna test doesn’t have this one.
 
I feel nauseous, dehydration, diarrhea, fatigue, weakness, rapid, heart rate, and trouble breathing.

I’ve heard someone on YouTube say that you can have a gene defect that makes you hyper sensitive to vitamin D.
I believe there are some infections that enter the cell through the Vitamin D receptor and taking Vitamin D will make it worse because the D gives the infection something to "ride" on. Dr Ruscio did a podcast about this several years ago.
 
Thanks man. I got his book and read it today, I also emailed him. I’ve never tried prog so this could be a big help. His descriptions also seem to fit my issues.

Are you a fan of the band GBV?
Indeed I am...very under-appreciated IMO. Also, even if the prog doesn't work for you, there may be other things you can try once you know if that is at the root of your issue. Infiniwell used to sell an anti-anxiety compound they called the "chill pill" which has a long-acting version of honokiol, but that doesn't sound like it would address the root cause, although perhaps it also counters adrenalin.
 
I believe there are some infections that enter the cell through the Vitamin D receptor and taking Vitamin D will make it worse because the D gives the infection something to "ride" on. Dr Ruscio did a podcast about this several years ago.
I left out coughing, sneezing and excessive nasal drainage as a symptom of taking more than 600 IU D3.
 
Indeed I am...very under-appreciated IMO. Also, even if the prog doesn't work for you, there may be other things you can try once you know if that is at the root of your issue. Infiniwell used to sell an anti-anxiety compound they called the "chill pill" which has a long-acting version of honokiol, but that doesn't sound like it would address the root cause, although perhaps it also counters adrenalin.
Saw them live a few times, awesome show!
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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