I’ve been on TRT for coming up to 3 years. Due to having various issues with it, I am considering trying to come off it. I was on cypionate for 1.5 years, then sustanon for a year and now testogel for last 4/5 months. I enquired about stopping with my clinic and they said that gel was less suppressive than injectables and so no PCT is required. Besides the half life clearance time of injections be gel, is recovery from gel actually quicker? From what he is saying it’s like suggesting that my fsh and lh would have risen since I moved to gel but I would have thought it would still be tanked regardless.
Transitioning from injectable to TD gel would cause less suppression overall of the hpta but keep in mind the gel will still have a strong impact on the hpta.
At least the TD formulation has a much shorter half-life and will be out of your system quicker.
Howdy, Basic question--I tried the search feature but could not find definitive information on the following. The specific question: Is there a dosing of Testosterone Enanthate (in mg per week) below which you can expect to preserve what is left of natural testosterone production? Does the...
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Because the
oral testosterone need hundreds of mg, it requires a specially formualted tablet to get absorbed by the lymphatic system. I'm on Jaetnzo @237 mg twice daily, or 3318 mg per week.
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FIGURE 1 | Percent change in mean gonadotropin levels (LH & FSH), from baseline through 6 months of testosterone treatment. Nasal testosterone (blue), dosed t.i.d., adapted from (15), n = 33.
Topical testosterone (orange), dosed daily, adapted from (9), n = 123.
IM injectable - 100 mg testosterone enanthate, (red), adapted from (10), n = 10.
All changes from baseline were statistically significant. Nasal testosterone—FSH p = 0.03, all others p < 0.001. Standard error calculated using the delta method
Novel methods for the treatment of low testosterone (2023) Julius Fink & Shigeo Horie Abstract Introduction Testosterone replacement therapy is a promising and growing field in modern healthcare. Several novel testosterone preparations aiming at providing an efficient drug without side...
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Figure 6: Effects of different types of T preparations on FSH (dark grey) and LH (light grey). Data from [22] [14]
My reply from an older thread:
Advantage to tapering down my test before starting my pct?
No need to taper when coming off testosterone using replacement doses.
When abusing testosterone/AAS in high-doses.....sure as it can soften the blow before starting a course of pct but keep in mind that the crash is inevitable and to what degree /length depends on many factors.
Recovery of the HPG axis will come down to dosage of testosterone/AAS used, duration of use, type of AAS used whether T only or T+AAS or T + multiple AAS), age of the individual.
Older men would tend to have a more difficult time recovering than younger men.
Higher doses and longer duration of use will have a greater negative impact on the recovery of the HPG axis
Use of nandrolone or trenbolone will have a greater negative effect on the recovery of the HPG axis
On average most men on trt are injecting 100-200 mg/week of testosterone only and the duration of use can be anywhere from months to years depending on whether the individual continues trt indefinitely or decides to come off such as in your case.
Use of PCT (post cycle therapy) will in no way prevent the crash following HPG axis recovery it will just soften the blow and speed up the recovery process/minimize the length of being in a hypogonadal state.
The main goal of PCT is to not only increase LH production which will stimulate the Leydig cells in the testes to produce endogenous testosterone (ITT) but most importantly making sure the testes are responsive to the LH stimulation as in many cases when on trt or steroids if no hCG was used during this time than the Leydig cells become dormant and the seminiferous tubules shrink which results in testicular atrophy due to shutdown of the HPG axis and LH/FSH production. This results in the Leydig cells no longer producing endogenous testosterone and the Sertoli/germ cells no longer producing sperm.
Use of hCG when on trt or steroids should aid in the recovery process when coming off as it mimics LH and will keep the Leydig cells active (producing some degree of ITT).
Even without the use of a PCT, the natural production of LH will kick in fairly quickly but natural endogenous production of testosterone let alone spermatogenesis can take much longer as the critical aspect of the recovery process is the responsiveness of the Leydig cells in the testes to the LH.
No one can say exactly how long it will take you to recover let alone how you will feel during the transition.
Some men on trt choose to stop cold turkey (no PCT) and recover okay with some bumps along the way whereas others may struggle before things get better.
Others choose to implement a PCT which may make the transition much quicker/smoother but again everyone is different as again there are numerous factors involved.
Some key points here!
* Some men on trt choose to stop cold turkey (no PCT) and recover okay with some bumps along the way whereas others may struggle before things get better.
* Others choose to implement a PCT which may make the transition much quicker/smoother but again everyone is different as again there are numerous factors involved.
