Metformin decreases high hematocrit

In the US (At least in Alabama) Red Cross will do a therapeutic phlebotomy (form on their web site) with a form signed off by your DR at no cost to you. They can still use some parts of your blood. They changed their rules a bit back. So if you are on "T", and pass the rest of the screening process, they will do it at no cost. I think I have posted some info on that elsewhere here. If you don't have the form signed off by your DR you may have to pay a fee of around $30.00 or so.
 
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My first year on TRT I was inching closer and closer to needing to donate blood due to high Hematocrit. I had started on Metformin in the summer of 2015, and by Dec of 2015 just when I thought I needed to donate off come blood, I had labs done and they showed my Hematocrit had fallen back underneath the high number........so no need to donate. I do not know if it was the Metformin, or that I had just finally stabalized my TRT where things had fallen into place on its own. However I am a very big fan of Metformin due to it's many benefits and very safe use.
 
My first year on TRT I was inching closer and closer to needing to donate blood due to high Hematocrit. I had started on Metformin in the summer of 2015, and by Dec of 2015 just when I thought I needed to donate off come blood, I had labs done and they showed my Hematocrit had fallen back underneath the high number........so no need to donate. I do not know if it was the Metformin, or that I had just finally stabalized my TRT where things had fallen into place on its own. However I am a very big fan of Metformin due to it's many benefits and very safe use.

What dosage of metformin you were using?
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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