Low DHT and high E2.

[TheDude]

Just got my follow up blood work back.

Total Test went from 150 to 800 (264-916 range).
Estradiol Sensitive went from 19 to 60 (8-35 range)
DHEA stayed level at 370.
SHBG stayed level at 14 (low)
Checked DHT this time and was at 30 (30-85 range)

Taking 40mg of Test Cyp EOD and 500IU of HCG every other time I do a Test Cyp injection, so every 4 days.

This was after 3 months on protocol.

Energy levels are a little bit better. Libido is non-existent. Over all, not much different than before starting.

Any thoughts on if DHT should be increased or if
my E2 needs to start being addressed?

What type protocol would be next? Every day injections?

 

[Vince]

Feeling good can be a big issue for low SHBG guys as you probably know. I would agree, your next move should be trying daily injections of T, especially for your high E2.

 

[CoastWatcher]

Your intuition - that daily injections may be necessary - may well be correct. Low SHBG and high E2 despite a reasonable weekly total dose...daily shots may well be the solution.

 

[TheDude]

Your intuition - that daily injections may be necessary - may well be correct. Low SHBG and high E2 despite a reasonable weekly total dose...daily shots may well be the solution.

Will that help DHT as well?

 

[Country23030]

From what I have learned on this site, that may be your best bet. Hope you feel better and keep us posted. It is a marathon!

 

[Vince]

Will that help DHT as well?

No daily will not help your DHT.
This may help.
What Is Good about DHT? and how to raise it.
https://selfhacked.com/2016/06/09/hidden-benefits-dht-increase-reduce/

 

[Vince Carter]

Dailys did not help my DHT, or my E, but everyone is different, only you will find out by trying it and getting some months and several sets of labs. the more likely thing I see in post #1 is that 60 is high, it's high by most everyone's basis of you're experiencing a negative symptom (libido). Daily would be a better choice over Anastrozole at this time. DHT is less likely to be the problem.

 

[ERO]

To raise DHT, apply a small amount of topical T to your scrotum daily. Defy offers that as part of a protocol and it works in terms of raising your DHT. In my case I feel no benefit from higher DHT but with my low SHBG that no longer surprises me.

 

[TheDude]

Dailys did not help my DHT, or my E, but everyone is different, only you will find out by trying it and getting some months and several sets of labs. the more likely thing I see in post #1 is that 60 is high, it's high by most everyone's basis of you're experiencing a negative symptom (libido). Daily would be a better choice over Anastrozole at this time. DHT is less likely to be the problem.

Defy recommended applying testosterone cream daily to the scrotum to increase DHT, also adding an AI of 0.125mg twice a week to lower Estrogen. Seems reasonable, right?

 

[Vince Carter]

I use the cream to the scrotum every night and it does work, and yes, .125mg is a very low dose and wouldn't be unreasonable