Long term health effects of testosterone replacement

That is an enormously open-ended question. Are you asking what the beneficial effects of TRT are? The possible complications that all men taking testosterone need to be aware of? Are you wondering about the scare-stories the press loves to report about the "negative" impact of testosterone treatment? There's an immense amount of information here on the forum, particularly in the sticky posts, that deal with all of these topics.
 
Millions of American men use a prescription testosterone gel or injection to restore normal levels of the manly hormone. The ongoing pharmaceutical marketing blitz promises that treating "low T" this way can make men feel more alert, energetic, mentally sharp, and sexually functional. However, legitimate safety concerns linger. For example, some older men on testosterone could face higher cardiac risks.
"Because of the marketing, men have been flooded with information about the potential benefit of fixing low testosterone, but not with the potential costs," says Dr. Carl Pallais, an endocrinologist and assistant professor of medicine at Harvard Medical School. "Men should be much more mindful of the possible long-term complications."
http://www.health.harvard.edu/mens-...safe-take-a-breath-before-you-take-the-plunge
 
Like CW stated, this forum is loaded with testimonies and stories from members. Almost 8 years for me, I don't have anything "bad" to say about it. It can be a bit of a learning curve getting familiar with what protocol works best for you (dosages, frequencies, ..), plus finding the right balance to keep E2 in check, and well being in general. It only gets bad if it's mismanaged by the patient and/or the doctor.
 
I would like to hear the good and bad from long term personal use.
I've only been on a couple of years but I will have to say the benefits for me way out weigh the negatives and there's no way I would ever want to go back to a low testosterone state.
 
With regular checkups and labs, I can't see about something negative happening that can't be treated or trt stopped to resolve it.
Like others said, living a bad life because of low t........th "negatives" already happened.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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