A concern some have voiced is that long term HRT may lose its efficacy. That users may have a honeymoon period, maybe lasting years, but over time, responsiveness to T or other hormones may diminish, and that a "tolerance" of sorts builds up, and that dosages may need to be continually increased to maintain the same effect. And then consequently, these increased dosages may present further complications for patients.
My questions are:
- Is there any evidence that this is the case?
- If these is such evidence, could that be attributable just to natural age related decline, and the need for increasing exogenous quantities to compensate? Or is that not really the case, as endogenous production basically halts anyway whenever supplemental T is utilized?
- Long term users: do you find that your treatment is less effective, or has it been possible to find a stable protocol that keeps you at baseline?
- I remember hearing of a report recently released about long term improvement in health outcomes for TRT users. Can anyone provide more information or links to that? Are there any other studies that show long term results for average TRT patients?
Aside from reduced fertility, perhaps my main hesitation is about becoming a 'guinea pig' and subjecting myself to possible unknown side effects down the line. I know some of the men here, including Nelson, have been using TRT for decades, and would love input from anyone in that position, especially since I am considering a more or less lifelong commitment.
Thanks in advance.
My questions are:
- Is there any evidence that this is the case?
- If these is such evidence, could that be attributable just to natural age related decline, and the need for increasing exogenous quantities to compensate? Or is that not really the case, as endogenous production basically halts anyway whenever supplemental T is utilized?
- Long term users: do you find that your treatment is less effective, or has it been possible to find a stable protocol that keeps you at baseline?
- I remember hearing of a report recently released about long term improvement in health outcomes for TRT users. Can anyone provide more information or links to that? Are there any other studies that show long term results for average TRT patients?
Aside from reduced fertility, perhaps my main hesitation is about becoming a 'guinea pig' and subjecting myself to possible unknown side effects down the line. I know some of the men here, including Nelson, have been using TRT for decades, and would love input from anyone in that position, especially since I am considering a more or less lifelong commitment.
Thanks in advance.
