Libido Lost

A little background info.

I have a pituitary tumor, diagnosed in 2018. Been on TRT since 2019. On thyroid meds, and cortisol is ok. I've been taking HGH .4 once a day for 2 months roughly. Its killing my libido, and I dont understand why. I took HGH a year ago, and the same thing happen, and I stopped and my libido came back. I actually need the HGH, cause I failed a stim test, and my endocrinologist prescribed me Genotropin. Prolactin is normal, and I even took some cabergoline anyway, just to see if it helped. I also tried a AI, small dosage ,25 Anastrazole, and nothing helped. I cant understand why HGH does this to me, and when I stop it, my libido comes back.

Estrogen is at 30 ultrasensitive

Testosterone is at a 920

No recent labs on Free test or SBHG but these are always in range, including the last time I had this problem.

Free T4 is 1.5
Free T3 is 4.1
TSH is non irrelevant in my case

Cortisol is a 9 in the monring

IGF-1 last test was a 161

Prolactin was a 5

CBC and CMP labs are normal

A1C is a 5.4
 
I’m confused, normally growth hormone deficiency causes low libido.

Maybe your HGH dosage is too high.

It’s best to create only one thread rather than scattering responses across two threads.
 
I’m confused, normally growth hormone deficiency causes low libido.

Maybe your HGH dosage is too high.

It’s best to create only one thread rather than scattering responses across two threads.
I've thought that maybe it was too high as well, cause looking at the symptoms for HIGH hgh that is seen in Acromegaly patients are lost of libido and erectile dysfunction. I thought .4 was low. Its only a little over 1 IU
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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