KYZATREX® - A NEW ORAL TESTOSTERONE & Why It's Better Than Injections

madman · Sep 3, 2025

Show notes:

(0:00) Intro
(1:01) The 13-year FDA journey and breaking stigmas
(4:09) Why it’s different from other oral testosterone
(6:12) Mimicking the body’s natural testosterone rhythm
(9:10) Estrogen balance, side effects, and fertility concerns
(13:51) Testosterone’s role in women’s health
(16:56) Free vs total testosterone and SHBG reduction
(24:08) Testosterone vs weight loss drugs
(29:55) Who should be cautious with testosterone therapy
(35:46) What counts as low testosterone?
(40:36) How to access KYZATREX and cost details

madman · Sep 3, 2025

Thread 'KYZATREX (oral testosterone undecanoate) Updates'

Oct 16, 2022

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 11 12. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg...

Thread 'Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)'

Apr 18, 2025

Again you heard it here first!

Nelson's domain the one and only!

Very informative webinar on the use of the newer oral TU formulations.

Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape is evolving. This webinar explores how oral testosterone is redefining treatment protocols, offering a convenient and effective alternative. With recent clinical insights and real-world data, we’ll discuss why practitioners should reconsider their approach to testosterone replacement therapy (TRT)....

madman · Sep 3, 2025

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Thread 'Testosterone Therapy Today: Clinical Advances & Safety with Dr. Abraham Morgentaler'

Sep 16, 2024

Dr. Morgentaler back in action!

Listen closely, loved this one!

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Synopsis

Dr. Morgentaler starts by sharing his pioneering journey with testosterone...

Thread 'The Science of Optimizing Your Testosterone'

Mar 4, 2025

Waiting on this one!

One of the few giants in the field!

In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in...

madman · Sep 3, 2025

Thread 'Re-evaluating the role of Free Testosterone and SHBG'

Sep 2, 2025

We do it big here at Nelson's stomping ground!

Dr. Leen Antonio (UZ Leuven)!

She has collaborated with the heavyweights in the field Dr. Bhasin and Dr. Jasuja (Brigham and Women's Hospital)), Dr. Fiers and team (UZ Ghent) on research related to free testosterone.

madman · Oct 12, 2025

Thread 'KYZATREX® Safe for your liver: Lymphatic Absorption'

Oct 12, 2025

* The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past.

Kyzatrex® (testosterone undecanoate) an oral testosterone therapy

Taken twice daily with food ideally a meal with some healthy fats

Foods with healthy fats help the body absorb the medicine, after swallowing the Kyzatrex® capsule dissolves in the digestive system and releases its...

madman · Nov 11, 2025

Thread 'The Testosterone Revolution: Affordable Oral TRT, Enclomiphene, and Personalized Low T Care'

Sep 10, 2025

* Starting today, providers will be able to prescribe tailored doses of compounded enclomiphene4 through the Hims & Hers platform and, for men experiencing sexual symptoms, offer personalized testosterone care that combines enclomiphene with tadalafil in a single dual-action treatment.

* Starting in 2026, that will include an exclusive branded oral testosterone (KYZATREX®) through a major health platform exclusive collaboration with Marius Pharmaceuticals.

https://www.hims.com/testosterone

...

madman · Nov 28, 2025

Thread 'Testosterone Pills Are Here. Why Are Guys Still Injecting?'

Nov 28, 2025

Testosterone Pills Are Here. Why Are Guys Still Injecting?

You might be able to switch things up.

www.menshealth.com

All bout dem GAINZZZ BRUH!

More T is better BRUH!

Top me up or better yet jack me up 24/7 off the hop BRUH!

Im a real man...ALPHA MALE BRUH!

That so called raging libido and titanium erections to boot LMFAO!

Unrealistic expectations!

Lets hammer the s**t out of our CNS and DOPAMINE while we are at it to boot LMFAO!

Tons of grown ass men running around with absurdly inflated FT and we are talking f**king trough here!

Brainwashed by that more T is better mentality pushed by all those clueless sheep...

madman · Nov 28, 2025

Thread 'TESTOSTERONE: A SAFETY UPDATE 2025'

Nov 16, 2025

Professor Michael Zitzmann

We also know hematocrit can be increased by testosterone preparations. It depends on the preparation, and we think that there is data that shows that the threshold of 52-54% should not be surpassed, and men should be controlled for the hematocrit especially in the first year of treatment every 3 months

Hematocrit & Thromboembolic Risk

* TTh increase Hematocrit - clinically relevant at >52-54%

* Recommended: Control Hematocrit every 3 months in the 1st year

...

Thread 'Testosterone Therapy and Erythrocytosis - the most common dose-limiting effect of testosterone therapy'

Apr 21, 2024

Testosterone Therapy and Erythrocytosis • The Blood Project

Introduction Androgens play a crucial role in the development and maintenance of: Male reproductive and sexual functions Body composition Erythropoiesis

www.thebloodproject.com

Introduction

Androgens play a crucial role in the development and maintenance of:

Male reproductive and sexual functions

Body composition

Erythropoiesis

Muscle and bone health

Cognitive function
Testosterone falls progressively with age and a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young...

Thread 'Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol'

Oct 12, 2025

Hot off the press!

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas!

Great presentation!

1:29:40-1:43:30

Conclusions

madman · Dec 6, 2025

Thread 'Marius Pharmaceuticals CEO Shalin Shah Invited to Speak at Landmark FDA Expert Panel on Testosterone Replacement Therapy for Men'

Dec 6, 2025

* This landmark event marks a pivotal moment in the advancement of men’s health and represents a major milestone for Marius, which has worked for years to elevate the scientific conversation surrounding testosterone and address longstanding misconceptions.

* Shah will join an esteemed group of panelists offering scientific, clinical, and regulatory insights into the risks, benefits, and appropriate use of testosterone replacement therapy.

“ The FDA turning its attention to testosterone, a fundamental driver of metabolic health, is a landmark development,” said...

madman · Dec 20, 2025

Thread 'Guidance on the use of oral TU : background, clinical considerations, and best practices'

Dec 20, 2025

When it comes to elevated hematocrit everyone is still so caught up on peak T levels!

As I have been preaching for years on here running too high a trough/steady-state FT will have a big impact here!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.

* Testosterone undecanoate (TU), developed in the 1970s, provided a solution by utilizing lymphatic absorption to bypass hepatic metabolism. The...

madman · Dec 24, 2025

Thread 'Treatment of Symptomatic Male Hypogonadism with New Oral Testosterone Therapies: A Comparative Review of Jatenzo, Tlando, and Kyzatrex'

Dec 24, 2025

https://www.mdpi.com/2305-6320/13/1/1#

Abstract

Symptomatic male hypogonadism, defined by low serum testosterone with associated clinical symptoms, is increasingly treated with testosterone replacement therapy. Traditional oral formulations were limited by hepatotoxicity and poor bioavailability, leading to reliance on injectable and transdermal routes. Recent advances in oral testosterone undecanoate formulations have introduced safer and more effective options. This review compares Jatenzo, Tlando, and Kyzatrex, highlighting their pharmacology, efficacy, safety, and...

madman · Dec 25, 2025

Thread 'JATENZO® Oral Testosterone Undecanoate - Efficacy, Flexible dosing and Safety Profile'

Dec 25, 2025

madman · Jan 3, 2026

Thread 'Oral TU Formulations (Andriol®, JATENZO®,TLANDO®, KYZATREX® for T Therapy'

Jan 3, 2026

* Oral TRT, particularly testosterone undecanoate (TU), offers notable convenience. TU is absorbed via the lymphatic system, bypassing first-pass hepatic metabolism, making it a promising agent for TRT. Its absorption, however, is influenced by dietary factors, such as lipid intake, thus the high-fat consumption promoting lymphatic absorption. Pharmaceutical technology developed TU formulations incorporate special self-emulsifying systems that enhance lymphatic absorption regardless of food fat content. This lymphatic absorption allows for stable testosterone levels...

madman · Jan 17, 2026

Thread 'Pill vs. Needle: The science behind the new oral therapy replacing injections'

Jan 17, 2026

Men are living, on average, 7 years less than women. According to Shalin Shah, CEO of Marius Pharmaceuticals, the medical community has ignored a cause for decades due to stigma, "gym bro" stereotypes, and outdated science.

In this episode, Daniel Robbins sits down with Shalin Shah to reveal why he believes testosterone is "less abused than caffeine" and yet still overly restricted. Shalin breaks down the "10 Cups of Coffee" rule (why weekly injections are bad for your body) and how he achieved FDA approval for an oral testosterone pill that mimics the body's...

madman · 2026-02-07T13:04:37-0600

madman said:
Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Thread 'Testosterone Therapy Today: Clinical Advances & Safety with Dr. Abraham Morgentaler'

Sep 16, 2024

Dr. Morgentaler back in action!

Listen closely, loved this one!

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Synopsis

Dr. Morgentaler starts by sharing his pioneering journey with testosterone...

madman

prostate cancer; testosterone; psa; trt; health

Replies: 9

Forum: Testosterone and Men's Health Articles

Thread 'The Science of Optimizing Your Testosterone'

Mar 4, 2025

Waiting on this one!

One of the few giants in the field!

In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in...

madman

hypogonadism; testosterone therapy; men'shealth

Replies: 5

Forum: Testosterone and Men's Health Articles

11:55-12:13

* you only need testosterone levels up for about 4-6 hrs in the day to produce an effect which works through the androgen receptor, the androgen receptor is present in every cell in the body so its not just a sex hormone it is a health hormone

Thread 'Testosterone a Hormone for Health and Survival in Men'

Dec 26, 2025

Listen closely here!

11:55-12:13

* you only need testosterone levels up for about 4-6 hrs in the day to produce an effect which works through the androgen receptor, the androgen receptor is present in every cell in the body so its not just a sex hormone it is a health hormone

Another powerhouse in the field!

* He presents compelling data showing that Testosterone Replacement Therapy (TRT), when bringing levels back to the normal range, can significantly reduce all-cause and cardiovascular death rates, improve quality of life, reduce insulin resistance (the...