Is Omega 3 an AR killer??

[1111]

Does DHA inhibit androgen receptors or mRNA??

 

[Vince]

AI review
Clinical studies on DHA and prostate cancer

• Investigational drug trials: A Phase II trial studied a DHA-paclitaxel compound for treating metastatic, hormone-refractory prostate cancer to determine its effectiveness and impact on overall survival and quality of life.
• Dietary and supplement interventions:
  • Mixed dietary results: Research has reported inconsistent findings regarding the effects of omega-3s on prostate cancer. Some observational studies show a link between higher fish consumption and lower prostate cancer mortality, while others have raised concerns about high omega-3 levels and cancer risk.
• Pre-surgery supplement trial: Another Phase IIb trial investigated a highly concentrated EPA supplement (a different omega-3 fatty acid) given before prostatectomy. It found that while tissue EPA levels increased, there was no significant reduction in the Ki-67 proliferation index compared to placebo.

 

[Vince]

• AI again
• Possible mechanisms: It is thought that omega-3s may help by reducing inflammation, which is a factor in cancer development and progression. Omega-3s can also slow the growth and division of cancer cells in lab settings.

 

[BadassBlues]

Does DHA inhibit androgen receptors or mRNA??

Interesting question, where did you get the idea to ask it?

Here is an interesting rat study, a bit off your question but still relative:

Effect of Omega-3 or Omega-6 Dietary Supplementation on Testicular Steroidogenesis, Adipokine Network, Cytokines, and Oxidative Stress in Adult Male Rats - PMC

This study was undertaken to elucidate the effect of omega-3 and omega-6 supplementation on the levels of different adipokines and cytokines, as well as the antioxidant system, in relation to male reproductive hormones and testicular functions. ...

pmc.ncbi.nlm.nih.gov

5. Conclusions​

The present study revealed for the first time the potential effects of omega-3 and omega-6 PUFAs on the levels of various adipokines in the male reproductive system. Both omega-3 and omega-6 PUFAs negatively influence the male reproductive function via inhibition of the kisspeptin-GnRH signaling pathway. The consumption of omega-3 and omega-6 PUFAs triggers anti-inflammatory properties via upregulation of apelin, adiponectin, irisin, and IL-10 and downregulation of leptin, resistin, visfatin, prostaglandins, and NF-κB and its downstream elements (IL-1β, IL-6, and TNF-α). Moreover, both omega-3 and omega-6 PUFAs ameliorate the testicular antioxidant status by scavenging ROS via increasing the levels of enzymes in the endogenous antioxidant system (SOD, CAT, and GPx).

 

[BadassBlues]

AI review
Clinical studies on DHA and prostate cancer

• Investigational drug trials: A Phase II trial studied a DHA-paclitaxel compound for treating metastatic, hormone-refractory prostate cancer to determine its effectiveness and impact on overall survival and quality of life.
• Dietary and supplement interventions:
  • Mixed dietary results: Research has reported inconsistent findings regarding the effects of omega-3s on prostate cancer. Some observational studies show a link between higher fish consumption and lower prostate cancer mortality, while others have raised concerns about high omega-3 levels and cancer risk.
• Pre-surgery supplement trial: Another Phase IIb trial investigated a highly concentrated EPA supplement (a different omega-3 fatty acid) given before prostatectomy. It found that while tissue EPA levels increased, there was no significant reduction in the Ki-67 proliferation index compared to placebo.

Most of the research on this topic is prostate cancer related.