Irritable and anxiety between doses

Got it and yes I do see the difference. But in this specific thread we were discussing a particular case and possible association, not a global blanket statement about all users of DHEA, seems like that's where a lot of the confusion was.

Understood, my only issue is the statement "DHEA has been shown to be an anxiety inducer" and that's simply not true and very different than saying "some men feel they experience increased anxiety with DHEA but no studies to fate have found such an effect" which covers the anecdotal nature of the claim. That's my only issue, full stop.

I find it interesting that you've never encountered someone recently put on DHEA experiencing new onset anxiety, I wonder if it is a dosing or complementary protocol effect. Worth looking into for sure.

Based on what you've studied: What do you see as DHEAs role in TRT? Do you typically include DHEA as part of a standard protocol or only when blood tests indicate a deficiency?

Thanks,
Scott

Only when blood tests indicate a deficiency. I'd include DHEA if labs showed DHEA (as DHEA-s) was low just as I would for T or other hormones. TRT is known to lower DHEA - and low DHEA levels associated with many things we all wish to avoid - so it's worth tracking along with the usual suspects of hormones, etc. and adding to the protocol. It can be quite a mood enhancer in women and act as mild TRT in them.

Will @ www.BrinkZone.com
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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