Injection Frequency, what do you recommend?

KenLowT

Active Member
Hi guys, I'm trying to get estradiol to come down a bit and hopefully stabilize levels some. I've noticed recently that my libido goes up slightly right before injection so I'm wondering if it's because my estradiol level. Right now I'm injecting 2x per week. After 6 weeks of this protocol I came down with this number:

Protocol: 100mg per week, 50mg 2x per week (Lab Corp)
Total T: 664 <264-916>
Free T: 12.4 <6.8-21.5>
Estradiol Sensitive: 39.1 <8-35.0>
SHBG: 25.9 <16.5-55.5>

At this SHBG, is 2x per week enough or would you recommend a M/W/F for more stable estradiol levels? I may need to just reduce my dosage, but I'll wait to talk to the doc about that. After reading horror stories about AI's, I'm wondering if this is worth a try before my first doc consult in two weeks.
 
I believe an EOD protocol will lower estrogen even further and you will feel better as a result. You have nothing to lose and everything to gain. As it stands now you may need an AI, an EOD protocol would allow you to not need an AI at all. Win, win.

Do not chase numbers, how are you feeling?

Also remember you only just reached a stable state and it could take months to feel like your old self again.
 
Should I wait till my consult in 2 weeks or is this change in injection frequency not that much of a biggie? Will the change be hard to deal with like my dosage change? If I do switch to Mon/Wed/Fri I'm going to definitely have to change my needle gauge. Currently hurting using 25g, 1 inch needle.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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