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Indirect way of monitoring E2 without blood test?

If you need to use an AI. Start low and increase slowly. You don't need to measure it in that process, you can go by symptoms. Once your symptoms resolved and it's stable, then you could measure E2 for reference.

That's what I'm trying to do, but still monitoring the number would help because overdosing causes same symptoms as underdosing. So far even 0.040mg (40mcg) of Anastrozole seems to have some effect. I think when I build tolerance - a higher dose will be required...
 
In my required use of an AI journey I tried it all over years time until I got to a dosage that did two things, cleared my body acne, and, improved EQ and Orgasm. I continued in a frequency of dosing and increased dosage my dosing until I didn't see any other improvements with a lower E value. Always symptom based and blood test for a reference point. Too and I started testing free Estrogen as my base blood indicator as opposed to LC/MS/MS values.
Whole point is...trial and error.
 
In my required use of an AI journey I tried it all over years time until I got to a dosage that did two things, cleared my body acne, and, improved EQ and Orgasm. I continued in a frequency of dosing and increased dosage my dosing until I didn't see any other improvements with a lower E value. Always symptom based and blood test for a reference point. Too and I started testing free Estrogen as my base blood indicator as opposed to LC/MS/MS values.
Whole point is...trial and error.
Thanks. What prescription AIs have you used besides Anastrozole? Have you tried Metformin?

What drugs/supplements and dosages have you found to be effective for you?
 
Anastrozole; and Ive used Exemestane(?) which didn't help but really threw out my lipid panel numbers that I had to stop that one. DIM was no help. Estrogen management for me is huge problem.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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