Increased sensitivity to estradiol after AI usage

Gman87

New Member
Hi,

I have used arimidex multiple times throughout the years. Every time I tend to use this, when I come off the drug, I appear to be more sensitive to estrogen than I was previously i.e. development of gyno at natty levels, cessation of hair loss etc. Bloodwork is all normal, I have pretty much an identical T:E ratio to what I did a couple of years ago, so the only thing I can think of is upregulated E receptors due to depriving it for extended period of times. Anyone else dealt with something similar, any solutions?

Cheers guys
 
Hi,

I have used arimidex multiple times throughout the years. Every time I tend to use this, when I come off the drug, I appear to be more sensitive to estrogen than I was previously i.e. development of gyno at natty levels, cessation of hair loss etc. Bloodwork is all normal, I have pretty much an identical T:E ratio to what I did a couple of years ago, so the only thing I can think of is upregulated E receptors due to depriving it for extended period of times. Anyone else dealt with something similar, any solutions?

Cheers guys
Is this an imposter @Gman86 ?
 
Hi,

I have used arimidex multiple times throughout the years. Every time I tend to use this, when I come off the drug, I appear to be more sensitive to estrogen than I was previously i.e. development of gyno at natty levels, cessation of hair loss etc. Bloodwork is all normal, I have pretty much an identical T:E ratio to what I did a couple of years ago, so the only thing I can think of is upregulated E receptors due to depriving it for extended period of times. Anyone else dealt with something similar, any solutions?

Cheers guys
I suspect nobody here used it the way you have used arimidex.
Maybe it's sort of a rebound effect. DHT matters too.
 
Maybe it's sort of a rebound effect.
I experienced a rebound effect after coming off an AI, way overly sensitive to estrogen temporarily. It felt like I was having a hard attack so I stopped TRT for 2 weeks and then restarted.

I'm natty now baby.
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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