IM vs. SC

advantages and disadvantages of Cypionate IM vs. SC as far as the effect on testosterone levels. Is there is difference?
For many people, yes absolutely, big difference! For you? We have no idea.

Using made up numbers, 20% of people will prefer SC injections and have better results. 50% of people will see no difference at all between SC and IM. 30% of people will have significantly lower testosterone levels and higher E2 with SC (and higher T and lower E2 with IM).

Was this response helpful? I won't be offended if you say no, because the only way to answer this question is for every individual to try both.
 
In controlled studies, no differences have been observed in total absorption. That is, total areas under the serum level response curves are similar for IM and SC. However, the response curves may have different shapes that vary with the delivery method, and also between individuals. In particular, it's generally expected that serum levels may rise higher and fall lower with IM compared to SC. However, average levels attained by the differing injection methods remain about the same.

Contradictory anecdotal reports must be considered suspect because they are extrapolating from one or two measurements, rather than taking samples every hour or so. Even so, it's quite plausible that the differing response curves result in differing subjective responses, and possibly even in differing rates of aromatization. It's an area that needs further study.
 
Alternate. Cover all the bases. Shallow IM and deep SQ for the win. Bonus if you hit right on the edge.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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