I need help with Low E2. I’m at my wits end.

AhmetAtay

Member
I’ve been struggling with low E2 for the longest time. Started off my TRT 36 mg daily test CYP, 200 IU HCG daily, and 0.0625 mg anastrozole twice per week. Dropped the AI due to low E2 symptoms (mostly achy knees, lethargy, difficulty maintaining/getting erection).

Bloodwork showed T = 3100 ng/dL, E2 = 112 ultrasensitive.

Dropped T down to 100 mg. No AI. 250 IU HCG EOD. Total T is 1300, E2 is 16.

I have horrible low E2 symltoms. Last time I took an AI was weeks ago. I do take a multivitamin with zinc in it that I might try cutting out.

The only thing that gives me relief is injecting 1000 IU HCG. For obvious reasons, I don’t think this is a sustainable approach.

I’m reaching out to Dr. Calkins at Defy to get estradiol cream.

I can’t stand it anymore. My symptoms include tingling/numbness in hands, dizziness, excessive fatigue, loss of libido, frequent urination, insane brain fog.

I take 5 mg Pregnenolone sublingually before bed because I’m low in it. Also 5 mg SR melatonin.

I might also try some estradiol valerate pills. Any ideas?
 
Also forgot to mention:

I’ve been dealing with some thyroid issues.

Waking body temperature has been 93-94 Fahrenheit with a maximum daily temperature of 96.6. Labs showed TSH of 1.1, T4 was normal at 4.6, but free T3 was low. I suspected high RT3 so I ordered a new set of labs of TSH/Free T4, Free T3 and RT3.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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